Papandreou Dimitrios, Rousso Israel, Mavromichalis Ioannis
2nd Department of Pediatrics, Aristotle University of Thessaloniki, School of Medicine, St Kiriakidi 1 Thessalonki, Greece.
Clin Nutr. 2007 Aug;26(4):409-15. doi: 10.1016/j.clnu.2007.02.002. Epub 2007 Apr 20.
Non-alcoholic fatty liver disease (NAFLD) is probably the most common cause of liver disease in the pediatric community. It is closely associated with obesity and insulin resistance. NAFLD may lead to non-alcoholic steatohepatitis (NASH). Although NASH is a prerequisite for the definition of NAFLD in adults and children, distinct differences are often apparent in the extent or location of fat, inflammation and fibrosis. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to summarize what is known about pediatric NAFLD in terms of prevalence, pathogenesis, diagnosis, histology and treatment.
非酒精性脂肪性肝病（NAFLD）可能是儿科群体中最常见的肝病病因。它与肥胖和胰岛素抵抗密切相关。NAFLD可能会导致非酒精性脂肪性肝炎（NASH）。尽管NASH是成人和儿童NAFLD定义的先决条件，但在脂肪、炎症和纤维化的程度或位置上，往往存在明显差异。NAFLD的诊断通常可通过影像学检查来实现；然而，对该疾病进行分期则需要进行肝活检。目前的治疗依赖于体重减轻和运动，尽管各种胰岛素增敏剂、抗氧化剂和药物看起来很有前景。本综述的目的是总结在患病率、发病机制、诊断、组织学和治疗方面关于儿童NAFLD的已知情况。
