Suppr超能文献

儿童非酒精性脂肪性肝病的诊断与分期:传统超声是答案吗?

Diagnosis and Staging of Pediatric Non-Alcoholic Fatty Liver Disease: Is Classical Ultrasound the Answer?

作者信息

Papachristodoulou Angeliki, Kavvadas Dimitrios, Karamitsos Athanasios, Papamitsou Theodora, Chatzidimitriou Maria, Sioga Antonia

机构信息

Laboratory of Histology and Embryology, School of Medicine, Faculty of Health, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

2nd Department of Ophthalmology, School of Medicine, Faculty of Health, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

出版信息

Pediatr Rep. 2021 Jun 8;13(2):312-321. doi: 10.3390/pediatric13020039.

Abstract

The increased prevalence of non-alcoholic fatty liver disease (NAFLD) requires special attention in pediatric patients, as it manifests in them in a more severe and progressive way compared to adults. The implementation of the appropriate therapeutic interventions is determinant of the attempts to treat it. For that purpose, early diagnosis and staging of the disease is essential. The purpose of this review was to find and reveal the most appropriate diagnostic strategies and tools for diagnosis and staging of pediatric NAFLD/NASH based on their accuracy, safety and effectiveness. The methodology followed was that of the literature review. Particular emphasis was put on the recent bibliography. A comparative study of published articles about the diagnosis and management of pediatric NAFLD/NASH was also performed. In terms of diagnosis, the findings converged on the use of classical ultrasound. Ultrasound presented average sensitivity and specificity for diagnosing the disease in children, while in the adult population, sensitivity and specificity were significantly higher. Proton density fat fraction magnetic resonance imaging has been increasingly used for the diagnosis of steatosis in pediatric patients. Elastography is an effective tool for staging liver fibrosis and discriminating NASH from NAFLD in children. Even though liver biopsy is the gold standard, especially for NASH, it should be avoided for pediatric patients. Biochemical tests are less specific and less sensitive for the diagnosis of NAFLD, and some of them are of high cost. It seems that diagnostic imaging should be a first-line tool for the staging and monitoring pediatric NAFLD/NASH in order for appropriate interventions to be implanted in a timely way.

摘要

非酒精性脂肪性肝病(NAFLD)患病率的上升在儿科患者中需要特别关注,因为与成人相比,它在儿科患者中表现得更为严重且呈进行性发展。实施适当的治疗干预措施是治疗该病的关键。为此,疾病的早期诊断和分期至关重要。本综述的目的是基于准确性、安全性和有效性,寻找并揭示用于儿科NAFLD/NASH诊断和分期的最合适的诊断策略和工具。所采用的方法是文献综述。特别强调了近期的文献。还对已发表的关于儿科NAFLD/NASH诊断和管理的文章进行了比较研究。在诊断方面,研究结果集中在使用经典超声。超声在诊断儿童疾病时呈现出平均敏感性和特异性,而在成人中,敏感性和特异性显著更高。质子密度脂肪分数磁共振成像越来越多地用于儿科患者脂肪变性的诊断。弹性成像对于儿童肝纤维化分期以及区分NASH和NAFLD是一种有效的工具。尽管肝活检是金标准,尤其是对于NASH,但儿科患者应避免进行。生化检测对NAFLD的诊断特异性较低且敏感性较差,并且其中一些成本较高。为了及时实施适当的干预措施,诊断成像似乎应成为儿科NAFLD/NASH分期和监测的一线工具。

相似文献

1
Diagnosis and Staging of Pediatric Non-Alcoholic Fatty Liver Disease: Is Classical Ultrasound the Answer?
Pediatr Rep. 2021 Jun 8;13(2):312-321. doi: 10.3390/pediatric13020039.
3
4
Diagnosis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Concepts.
Curr Pharm Des. 2018;24(38):4574-4586. doi: 10.2174/1381612825666190117102111.
6
Advances in ultrasound elastography for nonalcoholic fatty liver disease.
J Med Ultrason (2001). 2020 Oct;47(4):521-533. doi: 10.1007/s10396-020-01040-8. Epub 2020 Aug 3.
7
Radiologic evaluation of nonalcoholic fatty liver disease.
World J Gastroenterol. 2014 Jun 21;20(23):7392-402. doi: 10.3748/wjg.v20.i23.7392.
8
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: new trends and role of ultrasonography.
J Med Ultrason (2001). 2020 Oct;47(4):511-520. doi: 10.1007/s10396-020-01058-y. Epub 2020 Oct 21.

引用本文的文献

4
Efficacy of Ultrasound for the Detection of Possible Fatty Liver Disease in Children.
Diagnostics (Basel). 2024 Jul 31;14(15):1652. doi: 10.3390/diagnostics14151652.

本文引用的文献

1
Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome.
BMJ Open Gastroenterol. 2020 Aug;7(1). doi: 10.1136/bmjgast-2019-000352.
4
Comparison of diagnostic accuracy of screening tests ALT and ultrasound for pediatric non-alcoholic fatty liver disease.
Eur J Pediatr. 2019 Jun;178(6):863-870. doi: 10.1007/s00431-019-03362-3. Epub 2019 Mar 22.
5
Novel Ultrasonographic Fatty Liver Indicator Can Predict Hepatitis in Children With Non-alcoholic Fatty Liver Disease.
Front Pediatr. 2019 Jan 8;6:416. doi: 10.3389/fped.2018.00416. eCollection 2018.
6
Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.
Gastroenterology. 2019 Apr;156(5):1264-1281.e4. doi: 10.1053/j.gastro.2018.12.036. Epub 2019 Jan 18.
8
The search for noninvasive methods to identify liver fibrosis in children with nonalcoholic fatty liver disease.
Biomark Med. 2018 Mar;12(3):265-273. doi: 10.2217/bmm-2017-0038. Epub 2018 Mar 8.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验