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[人类肺毛滴虫病]

[Human pulmonary trichomonoses].

作者信息

Duboucher Christophe, Caby Stéphanie, Chabé Magali, Gantois Nausicaa, Delgado-Viscogliosi Pilar, Pierce Raymond, Capron Monique, Dei-Cas Eduardo, Viscogliosi Eric

机构信息

CHI de Poissy/Saint-Germain, Laboratoire d'anatomie pathologique, Saint-Germain-en-Laye, France.

出版信息

Presse Med. 2007 May;36(5 Pt 2):835-9. doi: 10.1016/j.lpm.2006.12.001. Epub 2007 Jan 8.

Abstract

Colonization of human lungs by various Trichomonas species is a frequent occurrence, but is unknown to most physicians. At this site of infection, the parasite develops into an amoeboid form that renders it unrecognizable. For this reason it has been overlooked until recently. Morphological identification is not feasible under these conditions and molecular tools provide the only means of identification. The species involved are not restricted to Trichomonas tenax, a saprophyte of the mouth that is usually cited in the rare cases of pleuropulmonary trichomoniasis reported in the literature. The recent discovery of species previously unknown in humans raises further questions, including the zoonotic potential of these microorganisms and the existence of species of animal origin that have adapted to humans. Anaerobiosis in poorly ventilated alveolar lumen, rather than immunodepression, seems to be the factor that promotes proliferation of this parasite. The diagnosis of trichomoniasis and its treatment by specific drugs will make it possible to evaluate the pathogenicity of these parasites.

摘要

多种毛滴虫在人类肺部定殖是常有的事,但大多数医生对此并不了解。在这个感染部位,寄生虫会发展成变形虫形态,使其难以辨认。因此,直到最近它一直被忽视。在这些情况下,形态学鉴定不可行,分子工具是唯一的鉴定手段。涉及的物种不仅限于口腔腐生菌口腔毛滴虫,文献中报道的罕见胸膜肺毛滴虫病病例通常会提及该菌。最近在人类中发现了以前未知的物种,这引发了更多问题,包括这些微生物的人畜共患病潜力以及已适应人类的动物源物种的存在。通风不良的肺泡腔内的厌氧环境,而非免疫抑制,似乎是促进这种寄生虫增殖的因素。毛滴虫病的诊断及其用特定药物治疗将使评估这些寄生虫的致病性成为可能。

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