Matthew Maurice A, Yang Nawu, Ketzis Jennifer, Mukaratirwa Samson, Yao Chaoqun
Department of Biomedical Sciences, One Health Centre for Zoonosis and Tropical Veterinary Diseases, Ross University School of Veterinary Medicine, Basseterre P.O. Box 334, Saint Kitts and Nevis.
Trop Med Infect Dis. 2023 Jan 12;8(1):60. doi: 10.3390/tropicalmed8010060.
is a flagellated protozoan parasite found in the oral cavities of humans and animals and has been associated with periodontal disease, the most prevalent inflammatory disease affecting them all. Studies have shown that can cause damage to mammalian cells and secretes virulent proteins, such as cysteine. It is presently considered zoonotic. Despite the few studies that have been done, the pathogenicity of this oral protozoan is still not fully understood. A database search was performed in July 2022 using PubMed and Google Scholar to retrieve data eligible for this study. PRISMA-ScR guidelines were followed to conduct this scoping review. A total of 321 articles were found with 87 included in this review after applying the exclusion criteria. Due to its increasing prevalence worldwide in both humans and dogs, detecting and elucidating the pathogenicity of this parasite is paramount for effective global control and prevention of periodontal disease. However, there is a paucity in the literature on this neglected zoonotic trichomonad, which is in large contrast to the closely related human pathogen . Here, we comprehensively review the history, morphology and reproduction, host, prevalence, diagnosis, pathogenicity, control, and prevention of . Hopefully, this article will call attention to both medical and veterinary professionals as well as epidemiologists on this most neglected and zoonotic protozoan. More epidemiological and clinical studies need to be conducted on to gain a better understanding of its pathogenicity, to increase the chances of developing effective drugs to aid in the control of this oral parasite, and reduce the spread of periodontal disease worldwide.
是一种在人类和动物口腔中发现的有鞭毛的原生动物寄生虫，与牙周病有关，牙周病是影响它们所有人的最普遍的炎症性疾病。研究表明，它会对哺乳动物细胞造成损害，并分泌有毒蛋白质，如半胱氨酸。目前它被认为是人畜共患病原体。尽管已经进行了一些研究，但这种口腔原生动物的致病性仍未完全了解。2022年7月使用PubMed和谷歌学术进行了数据库搜索，以检索符合本研究的数据。遵循PRISMA-ScR指南进行了这项范围审查。共发现321篇文章，应用排除标准后，本综述纳入了87篇。由于其在全球范围内人类和犬类中的患病率不断上升，检测和阐明这种寄生虫的致病性对于全球有效控制和预防牙周病至关重要。然而，关于这种被忽视的人畜共患毛滴虫的文献很少，这与密切相关的人类病原体形成了鲜明对比。在这里，我们全面回顾了它的历史、形态和繁殖、宿主、患病率、诊断、致病性控制和预防。希望本文能引起医学和兽医专业人员以及流行病学家对这种最被忽视的人畜共患原生动物的关注。需要对它进行更多的流行病学和临床研究，以更好地了解其致病性，增加开发有效药物以帮助控制这种口腔寄生虫的机会，并减少牙周病在全球的传播。
