长期β-肾上腺素能阻滞剂治疗后运动时的心血管及交感神经反应
Cardiovascular and sympathetic response to exercise after long-term beta-adrenergic blockade.
作者信息
Raine A E, Pickering T G
出版信息
Br Med J. 1977 Jul 9;2(6079):90-2. doi: 10.1136/bmj.2.6079.90.
Abstract
The response to dynamic exercise was investigated in 21 patients receiving long-term treatment with beta-adrenoceptor antagonists and 22 controls. An electrocardiogram (ECG) and blood pressure were recorded before and after treadmill exercise, and plasma dopamine-beta-hydroxylase (DBH) activity was measured as an index of changes in sympathetic activity. Heart rate and blood pressure were lower at rest and throughout exercise in treated patients, although the pressor effect of exercise was not reduced. The ECG P-R interval was lengthened, and in addition the Q-T interval was prolonged. After exercise, plasma DBH activity was significantly increased in controls but not in treated patients. We conclude that long-term administration of beta-adrenergic blockers increases myocardial repolarisation time and reduces sympathetic nervous activity. These actions may contribute to the antiarrhythmic and hypotensive effects of long-term beta-blockade.
摘要
对21例接受β-肾上腺素能受体拮抗剂长期治疗的患者和22例对照者进行了动态运动反应的研究。在跑步机运动前后记录心电图（ECG）和血压，并测量血浆多巴胺-β-羟化酶（DBH）活性作为交感神经活动变化的指标。治疗组患者在静息时和整个运动过程中的心率和血压较低，尽管运动的升压作用并未降低。心电图P-R间期延长，此外Q-T间期也延长。运动后，对照组血浆DBH活性显著增加，而治疗组患者未增加。我们得出结论，长期给予β-肾上腺素能阻滞剂可延长心肌复极时间并降低交感神经活动。这些作用可能有助于长期β受体阻滞剂的抗心律失常和降压作用。
相似文献
1
Cardiovascular and sympathetic response to exercise after long-term beta-adrenergic blockade.长期β-肾上腺素能阻滞剂治疗后运动时的心血管及交感神经反应
Br Med J. 1977 Jul 9;2(6079):90-2. doi: 10.1136/bmj.2.6079.90.
2
Effect of beta-adrenergic blockade on circulating catecholamines and dopamine-beta-hydroxylase activity during exercise in normal subjects.β-肾上腺素能阻滞剂对正常受试者运动期间循环儿茶酚胺及多巴胺-β-羟化酶活性的影响。
Am Heart J. 1983 May;105(5):777-82. doi: 10.1016/0002-8703(83)90240-5.
3
4
Exercise tolerance and compensatory sympathetic tone during beta-blockade after myocardial infarction.心肌梗死后β受体阻滞剂治疗期间的运动耐量和代偿性交感神经张力
Med Sci Sports Exerc. 1986 Aug;18(4):396-401.
5
Systemic, pulmonary and coronary haemodynamic actions of the novel dopamine receptor agonist in awake pigs at rest and during treadmill exercise Z1046.新型多巴胺受体激动剂Z1046对清醒猪在静息及跑步机运动时的全身、肺循环及冠状动脉血流动力学作用
Br J Pharmacol. 1997 Mar;120(6):1101-13. doi: 10.1038/sj.bjp.0701022.
6
Hemodynamic response to exercise after beta-adrenergic blockade in normal and labile hypertensive patients.正常和不稳定型高血压患者β-肾上腺素能阻滞剂治疗后运动的血流动力学反应
Cardiology. 1970;55(2):105-13. doi: 10.1159/000169273.
7
Cardiovascular effects of the novel Ca2+-sensitiser EMD 57033 in pigs at rest and during treadmill exercise.新型Ca2+敏化剂EMD 57033对静息及跑步机运动状态下猪的心血管效应。
Br J Pharmacol. 1997 Dec;122(7):1257-70. doi: 10.1038/sj.bjp.0701491.
8
Influence of intrinsic sympathomimetic activity of beta-adrenoceptor blockers on the heart rate and blood pressure responses to graded exercise.β-肾上腺素能受体阻滞剂的内在拟交感活性对心率及血压对分级运动反应的影响。
Br J Clin Pharmacol. 1981 Sep;12(3):355-62. doi: 10.1111/j.1365-2125.1981.tb01226.x.
9
[Sympathetic responsiveness and antihypertensive effect of beta-receptor blockade in essential hypertension: the effect of atenolol (author's transl)].原发性高血压中β受体阻滞剂的交感反应性及降压作用：阿替洛尔的效应（作者译）
Dtsch Med Wochenschr. 1977 Apr 15;102(15):569-74. doi: 10.1055/s-0028-1104934.
10
The carvedilol's beta-blockade in heart failure and exercise training's sympathetic blockade in healthy athletes during the rest and peak effort.卡维地洛在心力衰竭中的β阻断作用和运动训练在健康运动员中的交感神经阻断作用，无论是在休息还是在峰值努力时。
Cardiovasc Ther. 2010 Apr;28(2):87-92. doi: 10.1111/j.1755-5922.2009.00113.x.
引用本文的文献
1
Flurbiprofen interaction with single doses of atenolol and propranolol.氟比洛芬与单剂量阿替洛尔和普萘洛尔的相互作用。
Br J Clin Pharmacol. 1984 Dec;18(6):861-6. doi: 10.1111/j.1365-2125.1984.tb02556.x.
2
Effect of prolonged beta-adrenoceptor blockade on heart weight and ultrastructure in young rabbits.长期β-肾上腺素能受体阻断对幼兔心脏重量和超微结构的影响
Br J Pharmacol. 1980 Mar;68(3):363-71. doi: 10.1111/j.1476-5381.1980.tb14549.x.
3
How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta-adrenoceptor antagonists. A clue to the nature of their antihypertensive mechanism.内在拟交感活性如何调节对β-肾上腺素能受体拮抗剂的血流动力学反应。其降压机制本质的一个线索。
Br J Clin Pharmacol. 1982;13(Suppl 2):245S-257S. doi: 10.1111/j.1365-2125.1982.tb01922.x.
4
Adaptation of hypertensives to treatment with cardioselective and non-selective beta-blockers. Absence of correlation between bradycardia and blood pressure control, and reduction in slope of the QT/RR relation.高血压患者对心脏选择性和非选择性β受体阻滞剂治疗的适应性。心动过缓与血压控制之间无相关性，以及QT/RR关系斜率降低。
Br Heart J. 1980 Nov;44(5):473-87. doi: 10.1136/hrt.44.5.473.
5
Adaptational responses to prolonged beta-adrenoceptor blockade in adult rabbits.成年兔对长期β-肾上腺素能受体阻断的适应性反应。
Br J Pharmacol. 1980 Oct;70(2):205-18. doi: 10.1111/j.1476-5381.1980.tb07926.x.
6
Blood pressure behaviour during physical activity.身体活动期间的血压行为。
Sports Med. 1988 Jun;5(6):353-74. doi: 10.2165/00007256-198805060-00002.
7
QT time in patients treated with alprenolol or placebo after myocardial infarction.心肌梗死后接受阿普洛尔或安慰剂治疗患者的QT间期。
Br Heart J. 1979 Apr;41(4):452-5. doi: 10.1136/hrt.41.4.452.
8
Prevention and reversal of isolation-induced systolic arterial hypertension in rats by treatment with beta-adrenoceptor antagonists.通过β-肾上腺素能受体拮抗剂治疗预防和逆转大鼠隔离诱导的收缩期动脉高血压。
Br J Pharmacol. 1979 Feb;65(2):205-13. doi: 10.1111/j.1476-5381.1979.tb07820.x.
本文引用的文献
1
The effect of propranolol (Inderal) on the electrocardiogram of normal subjects.普萘洛尔（心得安）对正常受试者心电图的影响。
Am Heart J. 1969 Feb;77(2):192-5. doi: 10.1016/0002-8703(69)90350-0.
2
Immediate hemodynamic effects of beta-adrenergic blockade with propranolol in normotensive and hypertensive man.普萘洛尔对血压正常和高血压男性进行β-肾上腺素能阻滞的即时血流动力学效应。
Circulation. 1968 Mar;37(3):411-6. doi: 10.1161/01.cir.37.3.411.
3
Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.
4
Beta adrenergic blockade in hypertension. Practical and theoretical implications of long-term hemodynamic variations.高血压中的β肾上腺素能阻滞剂。长期血流动力学变化的实际和理论意义。
Am J Cardiol. 1972 May;29(5):633-40. doi: 10.1016/0002-9149(72)90164-6.
5
Functional distribution of right and left stellate innervation to the ventricles. Production of neurogenic electrocardiographic changes by unilateral alteration of sympathetic tone.左右星状神经对心室的功能性分布。通过单侧交感神经张力改变产生神经源性心电图变化。
Circ Res. 1966 Apr;18(4):416-28. doi: 10.1161/01.res.18.4.416.
6
Hemodynamic changes at rest and during exercise in long-term beta-blocker therapy of essential hypertension.原发性高血压长期β受体阻滞剂治疗中静息及运动时的血流动力学变化。
Acta Med Scand. 1974 Jan-Feb;195(1-2):117-21. doi: 10.1111/j.0954-6820.1974.tb08107.x.
7
The electrophysiology of propranolol in man.普萘洛尔在人体中的电生理学。
Am Heart J. 1974 Dec;88(6):733-41. doi: 10.1016/0002-8703(74)90283-x.
8
Plasma propranolol levels in the quaniitative assessment of beta-adrenergic blockade in man.人体β-肾上腺素能阻滞定量评估中的血浆普萘洛尔水平
Br Med J. 1970 Sep 26;3(5725):731-4. doi: 10.1136/bmj.3.5725.731.
9
A comparison of the anti-arrhythmic actions of I.C.I. 50172 and (--)-propranolol and their effects on intracellular cardiac action potentials and other features of cardiac function.ICI 50172与（-）-普萘洛尔的抗心律失常作用比较及其对细胞内心脏动作电位和心脏功能其他特征的影响。
Br J Pharmacol. 1969 Oct;37(2):391-9. doi: 10.1111/j.1476-5381.1969.tb10576.x.
10
Effects of beta-adrenergic blockade during exercise in hypertensive and ischaemic heart-disease.运动期间β-肾上腺素能阻滞剂对高血压和缺血性心脏病的影响。
Lancet. 1967 Dec 9;2(7528):1217-20. doi: 10.1016/s0140-6736(67)90561-2.
Zotero 插件