Dobson A J, Alexander H M, Malcolm J A, Steele P L, Miles T A
Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, NSW.
Med J Aust. 1991;155(11-12):757-61. doi: 10.5694/j.1326-5377.1991.tb94029.x.
To test the hypothesis that stress generated by the Newcastle earthquake led to increased risk of heart attack and coronary death.
A natural experiment.
People living in the Newcastle and Lake Macquarie local government areas of New South Wales, Australia.
At 10.27 a.m. on 28 December 1989 Newcastle was struck by an earthquake measuring 5.6 on the Richter scale.
Myocardial infarction and coronary death defined by the criteria of the WHO MONICA Project and hospital admissions for coronary disease before and after the earthquake and in corresponding periods in previous years. Well established, concurrent data collection systems were used.
There were six fatal myocardial infarctions and coronary deaths among people aged under 70 years after the earthquake in the period 28-31 December 1989. Compared with the average number of deaths at this time of year this was unusually high (P = 0.016). Relative risks for this four-day period were: fatal myocardial infarction and coronary death, 1.67 (95% confidence interval [Cl]: 0.72, 3.17); non-fatal definite myocardial infarction, 1.05 (95% Cl: 0.05, 2.22); non-fatal possible myocardial infarction, 1.34 (95% Cl: 0.67, 1.91); hospital admissions for myocardial infarction or other ischaemic heart disease, 1.27 (95% Cl: 0.83, 1.66). There was no evidence of increased risk during the following four months.
The magnitude of increased risk of death was slightly less than that previously reported after earthquakes in Greece. The data provide weak evidence that acute emotional and physical stress may trigger myocardial infarction and coronary death.
检验“纽卡斯尔地震产生的压力导致心脏病发作和冠心病死亡风险增加”这一假设。
一项自然实验。
居住在澳大利亚新南威尔士州纽卡斯尔和麦夸里湖地方政府辖区的居民。
1989年12月28日上午10点27分,纽卡斯尔发生里氏5.6级地震。
根据世界卫生组织MONICA项目的标准定义的心肌梗死和冠心病死亡,以及地震前后和前几年相应时期因冠心病住院的情况。采用了完善的、同步的数据收集系统。
1989年12月28日至31日期间,地震后70岁以下人群中有6例致命性心肌梗死和冠心病死亡。与一年中这个时候的平均死亡人数相比,这一数字异常高(P = 0.016)。这四天的相对风险分别为:致命性心肌梗死和冠心病死亡,1.67(95%置信区间[Cl]:0.72,3.17);非致命性明确心肌梗死,1.05(95% Cl:0.05,2.22);非致命性可能心肌梗死,1.34(95% Cl:0.67,1.91);因心肌梗死或其他缺血性心脏病住院,1.27(95% Cl:0.83,1.66)。在接下来的四个月中没有风险增加的证据。
死亡风险增加的幅度略低于希腊地震后先前报道的幅度。数据提供了微弱的证据表明急性情绪和身体压力可能引发心肌梗死和冠心病死亡。