心肌细胞损伤标志物的个人病史[心肌梗死]。

A personal history of markers of myocyte injury [myocardial infarction].

作者信息

Ladenson Jack H

机构信息

Washington University, School of Medicine, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, St. Louis, MO, USA.

出版信息

Clin Chim Acta. 2007 May;381(1):3-8. doi: 10.1016/j.cca.2007.02.039. Epub 2007 Feb 28.

DOI:10.1016/j.cca.2007.02.039

PMID:17451663

Abstract

BACKGROUND

The measurement of proteins in blood to reflect damage to the heart is one of the most successful examples of easily measured biomarkers identifying a serious major health problem. The concept of using a blood test to reflect organ or cell injury requires a substance that is very abundant in the target cell, has a means of reaching blood, a reasonable half-life in blood, and ideally a specific form reflective only of the target cell in tissue. The myocyte's major role is contraction so proteins involved in contraction or the energy to support it should be good candidate markers.

CONCLUSIONS

All the various biomarkers that have been used to detect cardiac damage are involved in contraction or energy metabolism, but the markers evolved empirically starting with transaminases in the 1950s leading to troponins in the 1990s. This history is reviewed with reflections on my experiences with developing assays for CK-MB and Troponin I.

摘要

背景

通过检测血液中的蛋白质来反映心脏损伤，是易于检测的生物标志物识别严重重大健康问题的最成功范例之一。利用血液检测反映器官或细胞损伤这一概念，需要一种在靶细胞中含量非常丰富、能够进入血液、在血液中有合理半衰期且理想情况下仅反映组织中靶细胞特定形式的物质。心肌细胞的主要功能是收缩，因此参与收缩或支持收缩的能量的蛋白质应是良好的候选标志物。