通过计算机断层扫描测量未经治疗的甲状腺功能亢进症儿童和青少年的皮质骨密度较低。

Low cortical bone density measured by computed tomography in children and adolescents with untreated hyperthyroidism.

作者信息

Numbenjapon Nawaporn, Costin Gertrude, Gilsanz Vicente, Pitukcheewanont Pisit

机构信息

Center for Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

出版信息

J Pediatr. 2007 May;150(5):527-30. doi: 10.1016/j.jpeds.2007.01.045.

DOI:10.1016/j.jpeds.2007.01.045

PMID:17452230

Abstract

OBJECTIVE

To determine whether increased thyroid hormones levels have an effect on various bone components (cortical vs cancellous bone).

STUDY DESIGN

The anthropometric and 3-dimensional quantitative computed tomography (CT) bone measurements, including bone density (BD), cross-sectional area (CSA) of the lumbar spine and femur, and cortical bone area (CBA) of the femur, of 18 children and adolescents with untreated hyperthyroidism were reviewed and compared with those of age-, sex-, and ethnicity-matched historical controls.

RESULTS

No significant differences in height, weight, body mass index (BMI), or pubertal staging between patients and controls were found. Cortical BD was significantly lower (P < .001) in children and adolescents with hyperthyroidism compared with historical controls. After adjusting for weight and height, no difference in femur CSA between hyperthyroid children and historical controls was evident. No significant correlations among thyroid hormone levels, antithyroid antibody levels, and cortical BD values were found.

CONCLUSIONS

As determined by CT, cortical bone is the preferential site of bone loss in children and adolescents with untreated hyperthyroidism.

摘要

目的

确定甲状腺激素水平升高是否对各种骨成分（皮质骨与松质骨）有影响。

研究设计

回顾了18例未经治疗的甲状腺功能亢进症儿童和青少年的人体测量数据以及三维定量计算机断层扫描（CT）骨测量结果，包括骨密度（BD）、腰椎和股骨的横截面积（CSA）以及股骨的皮质骨面积（CBA），并与年龄、性别和种族匹配的历史对照进行比较。

结果

患者与对照组在身高、体重、体重指数（BMI）或青春期分期方面未发现显著差异。与历史对照相比，甲状腺功能亢进症儿童和青少年的皮质骨密度显著降低（P <.001）。在调整体重和身高后，甲状腺功能亢进症儿童与历史对照之间的股骨CSA没有明显差异。未发现甲状腺激素水平、抗甲状腺抗体水平与皮质骨密度值之间存在显著相关性。