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以病理性骨折为表现的甲状腺功能亢进症

Hyperthyroidism Presenting With Pathologic Fractures.

作者信息

Sarezky Margaret D, Corwin Daniel J, Harrison Victor S, Jacobstein Cynthia

机构信息

Department of Pediatrics,

Divisions of Emergency Medicine, and.

出版信息

Pediatrics. 2016 Feb;137(2):e20150169. doi: 10.1542/peds.2015-0169. Epub 2016 Jan 8.

DOI:10.1542/peds.2015-0169
PMID:26746406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4822824/
Abstract

Previous studies have shown that thyroid hormone directly stimulates bone resorption in in vitro organ culture, and in adults excess thyroid hormone is associated with decreased bone mineral density. There are limited data in children regarding the effect of hyperthyroidism on bone metabolism and even fewer instances in the literature of hyperthyroidism presenting with bone demineralization and fracture. We report a case of an 11-year-old boy with undiagnosed hyperthyroidism presenting with fractures and osteoporosis. This case emphasizes the importance of maintaining a broad differential diagnosis when a patient presents with a pathologic fracture.

摘要

以往的研究表明，甲状腺激素在体外器官培养中可直接刺激骨吸收，在成年人中，甲状腺激素过多与骨矿物质密度降低有关。关于甲状腺功能亢进对儿童骨代谢影响的数据有限，而文献中甲状腺功能亢进伴骨脱矿质和骨折的病例更是少之又少。我们报告一例11岁未确诊甲状腺功能亢进的男孩，其表现为骨折和骨质疏松。该病例强调了患者出现病理性骨折时进行广泛鉴别诊断的重要性。

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本文引用的文献

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Graves' disease in children.儿童格雷夫斯病。
Best Pract Res Clin Endocrinol Metab. 2014 Mar;28(2):233-43. doi: 10.1016/j.beem.2013.08.008. Epub 2013 Sep 6.
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Left-shifted relation between calcium and parathyroid hormone in Graves' disease.格雷夫斯病中钙与甲状旁腺激素之间的关系左移。
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Is there a link between Hashimoto's thyroiditis and primary hyperparathyroidism? A study of serum parathormone and anti-TPO antibodies in 2267 patients.桥本甲状腺炎与原发性甲状旁腺功能亢进之间存在关联吗？对2267例患者的血清甲状旁腺激素和抗甲状腺过氧化物酶抗体的研究。
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Femoral fracture as a rare presentation of prepubertal graves disease.股骨骨折作为青春期前格雷夫斯病的罕见表现。
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Bone disease in thyrotoxicosis.甲状腺毒症中的骨骼疾病。
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The skeletal consequences of thyrotoxicosis.甲状腺毒症的骨骼后果。
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Thyroid bone disease.甲状腺骨病
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