Cristani A, Cioni G, Mussini C, Tincani E, Ventura E
Clinica Medica III, Università, Policlinico, Modena.
Minerva Med. 1991 Oct;82(10):627-31.
Immunoglobulin (Ig) serum levels have been assayed in 729 patients with liver cirrhosis of different etiologies, in order to evaluate their prognostic value. Serum levels of three classes of Ig resulted mainly elevated in the three etiological groups (post-hepatitic, post-alcoholic, cryptogenetic) and they were significantly related to the severity of the liver disease, evaluated according to the Child-Turcotte score. The computerized analysis of the survival curves of patients with IgG, IgM, IgA values normal or elevated demonstrated an adverse prognostic rate in those with elevated Ig values. The difference among the survival curves, compared by the Lee-Desu method, was statistically significant (p less than 0.001). Our data suggest that the Ig levels can be considered as a prognostic index in liver cirrhosis patients.
为评估免疫球蛋白（Ig）血清水平的预后价值，我们检测了729例不同病因肝硬化患者的Ig血清水平。三类Ig的血清水平在三个病因组（肝炎后、酒精后、隐源性）中主要呈升高状态，且根据Child-Turcotte评分评估，它们与肝脏疾病的严重程度显著相关。对IgG、IgM、IgA值正常或升高患者的生存曲线进行计算机分析显示，Ig值升高的患者预后不良率较高。通过Lee-Desu方法比较生存曲线之间的差异，具有统计学意义（p<0.001）。我们的数据表明，Ig水平可被视为肝硬化患者的一个预后指标。
