Wegener M, Neuhausen P, Börsch G, Ricken D
Dtsch Med Wochenschr. 1986 Nov 7;111(45):1716-20. doi: 10.1055/s-2008-1068698.
Serum immunoglobulins (IgG, IgA, IgM) were prospectively determined in 524 consecutive patients with degenerative liver damage (mainly steatosis), fibrosis, chronic hepatitis, and cirrhosis, proven by biopsy or visually. Concerning alcohol consumption all patients were assigned to two groups according to previously defined criteria; those with regular alcohol abuse (at least 80 g/d) and those without or with irregular alcohol intake. Serum concentrations of all immunoglobulin classes significantly increased with progredient liver parenchymal destruction from steatosis to chronic hepatitis and fibrosis to cirrhosis. Significant differences in immunoglobulins, especially in IgA, between patients with or without alcohol consumption were not observed. These results indicate that serum immunoglobulin concentrations are related to the degree and not to the etiology (alcoholic/non alcoholic) of liver damage.
通过活检或肉眼检查确诊的524例连续性退行性肝损伤（主要为脂肪变性）、纤维化、慢性肝炎和肝硬化患者，前瞻性地测定了其血清免疫球蛋白（IgG、IgA、IgM）。关于饮酒情况，根据先前定义的标准将所有患者分为两组；有规律酗酒者（至少80克/天）和无饮酒或饮酒不规律者。随着肝实质从脂肪变性到慢性肝炎、纤维化再到肝硬化的进行性破坏，所有免疫球蛋白类别的血清浓度均显著升高。未观察到饮酒者与未饮酒者之间免疫球蛋白的显著差异，尤其是IgA。这些结果表明，血清免疫球蛋白浓度与肝损伤的程度有关，而与肝损伤的病因（酒精性/非酒精性）无关。
