Sinert R, Zehtabchi S, Desai S, Peacock P, Altura B T, Altura B M
Department of Emergency Medicine, State University of New Yourk, Downstate Medical Center, Brooklyn, NY 11203, USA.
Scand J Clin Lab Invest. 2007;67(3):317-26. doi: 10.1080/00365510601051441.
Prior studies have been equivocal about whether or not serum levels of the divalent ions calcium and magnesium are altered during different types of seizures. Magnesium is a potential modulator of seizure activity because of its ability to antagonize the excitatory calcium influx through the N-methyl-D-aspartate (NMDA) receptor. We hypothesize that serum ionized levels of calcium (Ca(2+)) and magnesium (Mg(2+)) would be altered significantly during certain types of seizures.
A convenience sample of seizure patients presenting to an emergency department (ED) were enrolled in this prospective study. Novel ion-selective electrodes were used to measure Ca(2+) and Mg(2+). Data were reported as mean values+/-standard deviations. Group comparisons were analyzed by ANOVA with post-hoc testing using the Bonferroni, or the Fisher exact test, where appropriate, alpha = 0.05 (two-tailed).
Forty-nine patients with seizure and 32 healthy racially matched controls were included in the study. Seizure patients had a significantly (p<0.001) lower mean Mg(2+), but not total serum Mg and a significantly (p<0.001) higher Ca(2+)/Mg(2+) ratio than that in controls.
We were able to show significantly lower Mg(2+) and higher ionized Ca(2+)/Mg(2+) ratios in seizure patients compared with a racially matched control group.
先前的研究对于不同类型癫痫发作期间血清中二价离子钙和镁的水平是否发生改变尚无定论。镁是癫痫活动的潜在调节因子，因为它能够通过N-甲基-D-天冬氨酸（NMDA）受体拮抗兴奋性钙内流。我们假设在某些类型的癫痫发作期间，血清中离子化钙（Ca(2+)）和镁（Mg(2+)）的水平会发生显著改变。
本前瞻性研究纳入了到急诊科就诊的癫痫患者的便利样本。使用新型离子选择性电极测量Ca(2+)和Mg(2+)。数据以平均值±标准差表示。组间比较采用方差分析，并在适当情况下使用Bonferroni事后检验或Fisher精确检验，α = 0.05（双侧）。
该研究纳入了49例癫痫患者和32名种族匹配的健康对照者。癫痫患者的平均Mg(2+)显著低于对照组（p<0.001），但血清总镁无差异，且Ca(2+)/Mg(2+)比值显著高于对照组（p<0.001）。
与种族匹配的对照组相比，我们发现癫痫患者的Mg(2+)显著降低，离子化Ca(2+)/Mg(2+)比值升高。
