Resnick L M, Laragh J H, Sealey J E, Alderman M H
N Engl J Med. 1983 Oct 13;309(15):888-91. doi: 10.1056/NEJM198310133091504.
We studied the relation of plasma renin activity to serum levels of ionized calcium and magnesium in 102 normotensive patients and in 98 patients with essential hypertension who were divided into low-renin, normal-renin, and high-renin groups. Serum magnesium levels were higher in patients with low-renin hypertension and lower in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.025 for both comparisons) or in normotensive controls (P less than 0.005, P less than 0.05, respectively). In contrast, serum levels of ionized calcium were lower in patients with low-renin hypertension and higher in patients with high-renin hypertension than in those with normal-renin hypertension (P less than 0.001, P less than 0.05, respectively) or in normotensive controls (P less than 0.001, P less than 0.05, respectively). Altogether, the range of plasma renin activity in essential hypertension shows a continuous negative correlation with the serum magnesium level (r = -0.60, P less than 0.001) and a positive correlation with the serum ionized calcium level (r = 0.44, P less than 0.001). Accordingly, plasma renin activity in hypertension may reflect or contribute to changes in calcium and magnesium fluxes across cell membranes.
我们研究了102名血压正常的患者以及98名原发性高血压患者（这些患者被分为低肾素、正常肾素和高肾素组）的血浆肾素活性与血清离子钙和镁水平之间的关系。低肾素型高血压患者的血清镁水平高于正常肾素型高血压患者（两组比较P均小于0.025），也高于血压正常的对照组（分别为P小于0.005和P小于0.05）；高肾素型高血压患者的血清镁水平低于正常肾素型高血压患者（两组比较P均小于0.025），也低于血压正常的对照组（分别为P小于0.005和P小于0.05）。相反，低肾素型高血压患者的血清离子钙水平低于正常肾素型高血压患者（分别为P小于0.001和P小于0.05），也低于血压正常的对照组（分别为P小于0.001和P小于0.05）；高肾素型高血压患者的血清离子钙水平高于正常肾素型高血压患者（分别为P小于0.001和P小于0.05），也高于血压正常的对照组（分别为P小于0.001和P小于0.05）。总体而言，原发性高血压患者的血浆肾素活性范围与血清镁水平呈持续负相关（r = -0.60，P小于0.001），与血清离子钙水平呈正相关（r = 0.44，P小于0.001）。因此，高血压患者的血浆肾素活性可能反映或促成跨细胞膜的钙和镁通量变化。
