Oates P S
Physiology M311, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Nedlands, WA, Australia.
Histol Histopathol. 2007 Jul;22(7):791-804. doi: 10.14670/HH-22.791.
The field of iron metabolism is moving rapidly. There have been significant advances in our understanding of how proteins carry out the process of iron absorption. The three main tissues involved in iron exchange are the enterocyte which contributes new iron to the system, the hepatocyte which stores and releases iron and the macrophages which recycles iron from effete red blood cells to the plasma. This review examines recent evidence into the function of the iron transporters divalent metal transporter and ferroportin in enterocytes. Evidence is also provided from the author's laboratory which presents an alternative hypothesis into how hepcidin a key regulator molecule might interact with ferroportin in enterocytes. It is proposed that ferroportin operates differently in enterocytes compared with macrophages. Specifically in enterocytes ferroportin appears to function in the uptake stage of iron absorption.
铁代谢领域发展迅速。我们对蛋白质如何执行铁吸收过程的理解有了重大进展。参与铁交换的三个主要组织是为系统提供新铁的肠上皮细胞、储存和释放铁的肝细胞以及将衰老红细胞中的铁循环回血浆的巨噬细胞。本综述研究了关于肠上皮细胞中铁转运蛋白二价金属转运体和铁转运蛋白功能的最新证据。作者实验室也提供了证据，提出了一种关于关键调节分子铁调素如何与肠上皮细胞中的铁转运蛋白相互作用的替代假说。有人提出，铁转运蛋白在肠上皮细胞中的运作方式与巨噬细胞不同。具体而言，在肠上皮细胞中，铁转运蛋白似乎在铁吸收的摄取阶段发挥作用。
