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[一种用于阿尔茨海默病早期检测的新型检测方法的描述]

[Description of a novel test for the early detection of Alzheimer's disease].

作者信息

Cuetos-Vega F, Menendez-González M, Calatayud-Noguera T

机构信息

Universidad de Oviedo, Facultad de Psicologia, Oviedo, Spain.

出版信息

Rev Neurol. 2007;44(8):469-74.

Abstract

INTRODUCTION

Diagnosing Alzheimer's disease (AD) as soon as possible is critical to achieve an effective treatment of patients.

AIM

To make up a test capable of differentiating those patients suffering from the early stages of AD compared to healthy people or patients with mild cognitive impairment (MCI).

SUBJECTS AND METHODS

A test with 10 memory and language tasks was applied to 85 people: 34 in the early stage of probable AD, 26 with MCI, and 25 healthy people. The groups did not differ with regard to age, sex or studies.

RESULTS

The analysis of variance showed significative differences between groups in all tasks as well as in the global score. Sensibility and specificity were calculated to MCI and AD.

CONCLUSIONS

We designed a new test to detect AD patients on an early stage that is quick and easy to apply. The preliminary scale results in controls, MCI and early AD are shown.

摘要

引言

尽早诊断阿尔茨海默病(AD)对于有效治疗患者至关重要。

目的

编制一种能够区分处于AD早期阶段的患者与健康人或轻度认知障碍(MCI)患者的测试。

对象与方法

对85人进行了一项包含10项记忆和语言任务的测试:34名可能处于AD早期阶段的患者、26名MCI患者和25名健康人。这些组在年龄、性别或学历方面没有差异。

结果

方差分析显示,在所有任务以及总体得分方面,各组之间存在显著差异。计算了针对MCI和AD的敏感性和特异性。

结论

我们设计了一种新的测试方法,用于在早期阶段检测AD患者,该方法快速且易于应用。展示了该初步量表在对照组、MCI和早期AD患者中的结果。

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