Oliveira A L, Reis R L, Li P
DePuy Orthopaedics, Inc., 700 Orthopaedics Drive, Warsaw, Indiana 46581, USA.
J Biomed Mater Res B Appl Biomater. 2007 Oct;83(1):258-65. doi: 10.1002/jbm.b.30791.
During the last few years Strontium has been shown to have beneficial effects when incorporated at certain doses in bone by stimulating bone formation. It is believed that its presence locally at the interface between an implant and bone will enhance osteointegration and therefore, ensure the longevity of a joint prosthesis. In this study we explore the possibility of incorporating Sr into nano-apatite coatings prepared by a solution-derived process according to an established biomimetic methodology for coating titanium based implants. The way this element is incorporated in the apatite structure and its effects on the stereochemistry and morphology of the resulting apatite layers was investigated, as well as its effect in the mineralization kinetics. By using the present methodology it was possible to incorporate increasing amounts of Sr in the apatite layers. Sr was found to incorporate in the apatite layer through a substitution mechanism by replacing Ca in the apatite lattice. The presence of Sr in solution induced an inhibitory effect on mineralization, leading to a decrease in the thickness of the mineral layers. The obtained Sr-substituted biomimetic coatings presented a bone-like structure similar to the one found in the human bone and therefore, are expected to enhance bone formation and osteointegration.
在过去几年中，已表明锶在以特定剂量掺入骨中时，通过刺激骨形成具有有益作用。据信，其在植入物与骨之间的界面处局部存在将增强骨整合，因此确保关节假体的使用寿命。在本研究中，我们探索了根据一种用于涂覆钛基植入物的既定仿生方法，将锶掺入通过溶液衍生法制备的纳米磷灰石涂层中的可能性。研究了该元素掺入磷灰石结构的方式及其对所得磷灰石层的立体化学和形态的影响，以及其对矿化动力学的影响。通过使用本方法，可以在磷灰石层中掺入越来越多的锶。发现锶通过取代磷灰石晶格中的钙，通过取代机制掺入磷灰石层中。溶液中锶的存在对矿化产生抑制作用，导致矿化层厚度减小。所获得的锶取代的仿生涂层呈现出类似于在人骨中发现的骨样结构，因此有望增强骨形成和骨整合。
