Wu Zhoujun, Feng Bo, Weng Jie, Qu Shuxin, Wang Jianxin, Lu Xiong
Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):486-92. doi: 10.1002/jbm.b.30895.
Incorporation of antibiotics in the apatite coatings on titanium surface is an effective step for surgical infections of titanium implant. In this work, antibiotics cephradine and traditional Chinese medicine salviae miltlorrhizae (SM) were incorporated in the simulated body fluid (SBF). The apatite coatings were coprecipitated with cephradine and SM by a biomimetic method. The research showed that in the biomimetic coprecipitation process cephradine containing carboxylic groups were beneficial to the apatite coprecipitation. X-ray diffraction patterns showed that cephradine had a positive effect on the crystal growth in terms of cystallinity. And also in the Fourier transformed infrared spectra, the organic groups corresponded with cephradine were also observed. However, little apatite formed on the titanium immersed in SBF with SM. Probably, SM was more absorbed on the surface when calcium and phosphate ions precipitated.
在钛表面的磷灰石涂层中掺入抗生素是预防钛植入物手术感染的有效措施。在本研究中，抗生素头孢拉定和中药丹参（SM）被掺入模拟体液（SBF）中。通过仿生方法使磷灰石涂层与头孢拉定和SM共沉淀。研究表明，在仿生共沉淀过程中，含羧基的头孢拉定有利于磷灰石的共沉淀。X射线衍射图谱显示，头孢拉定在结晶度方面对晶体生长有积极影响。在傅里叶变换红外光谱中也观察到了与头孢拉定对应的有机基团。然而，浸泡在含SM的SBF中的钛表面形成的磷灰石很少。可能是因为当钙和磷酸根离子沉淀时，SM更多地吸附在了表面。
