Ramulu Pradeep, Iliff Nicholas T, Green W Richard, Kuo Irene C
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cornea. 2007 May;26(4):484-6. doi: 10.1097/ICO.0b013e3180307667.
To report a case of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma with presumed intraocular involvement.
Observational case report.
A 73-year-old white man presented for a routine eye examination and was found to have a salmon-colored bulbar conjunctival mass of the left eye. Ultrasound showed a low-reflective mass with diffuse thickening of the ciliary body and choroid. Immunohistochemistry and flow cytometry of an incisional biopsy specimen suggested a polyclonal lesion. Treatment with topical steroids yielded no clinical improvement, and excisional biopsy was performed. A diagnosis of MALT lymphoma was made after polymerase chain reaction (PCR) analysis of the immunoglobulin heavy chain (IgH) locus revealed a clonal B-cell population.
Conjunctival MALT lymphoma can present without symptoms and can extend intraocularly. PCR analysis of the IgH locus can identify lesion clonality when immunohistochemistry and flow cytometry fail to do so.
报告1例疑似合并眼内受累的结膜黏膜相关淋巴组织（MALT）淋巴瘤病例。
观察性病例报告。
一名73岁白人男性因常规眼部检查就诊，发现左眼有一个鲑鱼色的球结膜肿物。超声显示低回声肿物，睫状体和脉络膜弥漫性增厚。切开活检标本的免疫组织化学和流式细胞术提示为多克隆病变。局部应用类固醇治疗后临床症状无改善，遂行切除活检。免疫球蛋白重链（IgH）基因座的聚合酶链反应（PCR）分析显示存在克隆性B细胞群体，确诊为MALT淋巴瘤。
结膜MALT淋巴瘤可无症状出现，并可向眼内蔓延。当免疫组织化学和流式细胞术无法识别病变的克隆性时，IgH基因座的PCR分析可予以鉴别。
