Henry Jerome A, O'Sullivan Gerard, Pandit Abhay S
Department of Mechanical and Biomedical Engineering, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.
World J Gastroenterol. 2007 Mar 7;13(9):1372-7. doi: 10.3748/wjg.v13.i9.1372.
The objective of this research was to use abdominal computed tomography (CT) scans to non-invasively quantify anthropometrical data of the human stomach and to concomitantly create an anatomically correct and distensible ex-vivo gastric model. Thirty-three abdominal CT scans of human subjects were obtained and were imported into reconstruction software to generate 3D models of the stomachs. Anthropometrical data such as gastric wall thickness, gastric surface area and gastric volume were subsequently quantified. A representative 3D computer model was exported into a selective laser sintering (SLS) rapid prototyping machine to create an anatomically correct solid gastric model. Subsequently, a replica wax template of the SLS model was created. A negative mould was offset around the wax template such that the offset distance was equivalent to that of the gastric wall thickness. A silicone with similar mechanical properties to the human stomach was poured into the offset. The lost wax manufacturing technique was employed to create a hollow distensible stomach model. 3D computer gastric models were generated from the CT scans. A hollow distensible silicone ex-vivo gastric model with similar compliance to that of the human stomach was created. The anthropometrical data indicated that there is no significant relationship between BMI and gastric surface area or gastric volume. There were inter- and intra-group differences between groups with respect to gastric wall thickness. This study demonstrates that abdominal CT scans can be used to both non-invasively determine gastric anthropometrical data as well as create realistic ex-vivo stomach models.
本研究的目的是利用腹部计算机断层扫描（CT）来非侵入性地量化人体胃部的人体测量数据，并同时创建一个解剖结构正确且可扩张的离体胃模型。获取了33名人类受试者的腹部CT扫描图像，并将其导入重建软件以生成胃部的3D模型。随后对胃壁厚度、胃表面积和胃体积等人体测量数据进行了量化。将一个具有代表性的3D计算机模型导出到选择性激光烧结（SLS）快速成型机中，以创建一个解剖结构正确的实体胃模型。随后，制作了SLS模型的复制蜡模板。在蜡模板周围设置一个负模，使其偏移距离与胃壁厚度相等。将一种机械性能与人体胃部相似的硅胶倒入该偏移处。采用失蜡制造技术创建了一个中空的可扩张胃模型。从CT扫描生成了3D计算机胃模型。创建了一个与人体胃部具有相似顺应性的中空可扩张离体硅胶胃模型。人体测量数据表明，体重指数（BMI）与胃表面积或胃体积之间没有显著关系。在胃壁厚度方面，不同组之间以及组内存在差异。本研究表明，腹部CT扫描可用于非侵入性地确定胃部人体测量数据，以及创建逼真的离体胃模型。
