Bouras E P, Delgado-Aros S, Camilleri M, Castillo E J, Burton D D, Thomforde G M, Chial H J
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Gut. 2002 Dec;51(6):781-6. doi: 10.1136/gut.51.6.781.
Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes.
Our aims were: to assess the accuracy of SPECT with three dimensional image analysis to measure balloon volumes in vitro; to compare gastric barostat balloon volumes measured post-meal and post-distension with total gastric volumes measured simultaneously with SPECT; to present normal gastric volume data for healthy adults; and to compare SPECT data in health with symptomatic post-fundoplication patients.
In vitro balloon volumes measured by SPECT were highly accurate (R(2)=0.99). When measured simultaneously by gastric barostat and SPECT, postprandial/fasting volume ratios (2.2 (0.12) (mean (SEM)) v 2.3 (0.15), respectively; p=0.6) and post-distension volume ratios (1.4 (0.1) v1.3 (0.1); p=0.2) were highly comparable. In females, postprandial gastric volumes (675 (14) v 744 (20) ml for males; p=0.004) and changes in gastric volumes (464 (14) ml v 521 (20) ml for males; p=0.01) measured by SPECT were significantly lower than in males. No effects of age or body mass index were noted. The postprandial/fasting gastric volume ratio by SPECT was lower in post-fundoplication patients (2.7 (0.2)) than in healthy controls (3.4 (0.1); p=0.003).
SPECT provides a non-invasive estimate of the effect of a meal on total gastric volume that is comparable to changes in balloon volume observed with the gastric barostat. The SPECT technique is promising for investigation of gastric volumes in health and disease and the effects of pharmacological agents.
胃容纳功能受损可能导致消化不良症状。已开发出一种使用单光子发射计算机断层扫描（SPECT）的非侵入性方法来测量胃容积。
我们的目的是：评估采用三维图像分析的SPECT测量体外球囊容积的准确性；比较餐后和扩张后通过胃压力测定仪测量的球囊容积与同时用SPECT测量的总胃容积；给出健康成年人的正常胃容积数据；并比较健康人与胃底折叠术后有症状患者的SPECT数据。
通过SPECT测量的体外球囊容积高度准确（R² = 0.99）。当同时通过胃压力测定仪和SPECT测量时，餐后/空腹容积比（分别为2.2（0.12）（均值（标准误））对2.3（0.15）；p = 0.6）和扩张后容积比（1.4（0.1）对1.3（0.1）；p = 0.2）具有高度可比性。在女性中，通过SPECT测量的餐后胃容积（男性为675（14）ml对744（20）ml；p = 0.004）和胃容积变化（男性为464（14）ml对521（20）ml；p = 0.01）显著低于男性。未观察到年龄或体重指数的影响。胃底折叠术后患者通过SPECT测量的餐后/空腹胃容积比（2.7（0.2））低于健康对照组（3.4（0.1）；p = 0.00３）。
SPECT提供了一种对进餐对总胃容积影响的非侵入性估计，这与用胃压力测定仪观察到的球囊容积变化相当。SPECT技术在研究健康和疾病状态下的胃容积以及药物作用方面很有前景。
