Dabrowska E, Błahuszewska K, Minarowska A, Kaczmarski M, Niedźwiecka-Andrzejewicz I, Stokowska W
Department of Social and Preventive Dentistry, Medical University of Białystok, Poland.
Adv Med Sci. 2006;51 Suppl 1:100-3.
Cystic fibrosis (CF) is one of the most common genetic diseases worldwide. It is caused by mutations of the gene situated on the long-arm of the 7th chromosome coding Cystic Fibrosis Transmembrane Conductance Regulator (CFTCR) which is responsible for the synthesis of cAMP-dependent membrane chloride channel located on the top surface of epithelial cells of exocrine glands. Accumulation of the secretion in the outlet ducts caused by a dysfunction or lack of CFTR proteins leads to abnormal activity of exocrine glands, especially in the respiratory and alimentary tracts. Carbohydrates, the main dietary component, supply energy to the body, but at the same time are the major cariogenic agent. The aim of the current study was to assess dental caries disease and oral hygiene in CF patients in the region of Podlasie.
The study involved 23 patients with cystic fibrosis, aged 2.5-24 years, from the Podlasie Province treated in the Outpatient Cystic Fibrosis Department of the Children's University Hospital in Białystok. Three age groups were distinguished: 1-5, 6-12, 13-24 years. The following were evaluated: caries incidence (percentage of patients with caries CI), caries intensity--based on the mean dmf/DMF score, oral hygiene--based on the dental plaque index (OHI-pl).
The incidence rate of caries was found to be very high both in the CF population and in the control group. In children with mixed dentition it was 100%. For permanent teeth, mean DMF score was 3.55 in group II and 10.9 in group III. In CF patients, dental plaque index was the highest in group III.
In CF patients, there is a serious risk of caries due to severe course of the disease, long-term administration of medications and high carbohydrate diet. CF patients should remain under constant dental care according to the individually designed programmes of oral health promotion and caries prophylaxis.
囊性纤维化（CF）是全球最常见的遗传性疾病之一。它由位于第7号染色体长臂上的基因发生突变引起，该基因编码囊性纤维化跨膜传导调节因子（CFTCR），负责合成位于外分泌腺上皮细胞顶面的cAMP依赖性膜氯化物通道。CFTR蛋白功能障碍或缺乏导致分泌液在排泄导管中积聚，从而导致外分泌腺活动异常，尤其是在呼吸道和消化道。碳水化合物作为主要饮食成分，为身体提供能量，但同时也是主要的致龋因素。本研究的目的是评估波德拉谢地区CF患者的龋齿疾病和口腔卫生状况。
本研究纳入了23例年龄在2.5至24岁之间、来自波德拉谢省的囊性纤维化患者，他们在比亚韦斯托克儿童医院门诊囊性纤维化科接受治疗。分为三个年龄组：1至5岁、6至12岁、13至24岁。评估以下指标：龋齿发病率（患龋患者百分比，CI）、龋齿严重程度——基于平均dmf/DMF评分、口腔卫生状况——基于牙菌斑指数（OHI-pl）。
CF人群和对照组的龋齿发病率均很高。在混合牙列儿童中，发病率为100%。恒牙方面，第二组的平均DMF评分为3.55，第三组为10.9。在CF患者中，第三组的牙菌斑指数最高。
由于疾病严重、长期用药和高碳水化合物饮食，CF患者存在严重的龋齿风险。CF患者应根据个体化设计的口腔健康促进和龋齿预防方案，持续接受牙科护理。
Zotero 插件