6-20 岁囊性纤维化患者的年龄相关性龋齿异质性及其相关危险因素：一项初步研究。
Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6-20 years: A pilot study.
机构信息
University of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA.
Seattle Children's Hospital, Cystic Fibrosis Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
出版信息
J Cyst Fibros. 2018 Nov;17(6):747-759. doi: 10.1016/j.jcf.2018.06.009. Epub 2018 Jul 10.
BACKGROUND
The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls.
METHODS
Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF.
RESULTS
Children ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF.
CONCLUSIONS
Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.
背景
囊性纤维化（CF）患者的龋齿风险相关文献与对照相比存在冲突。
方法
对华盛顿州单一诊所 6-20 岁 CF 患者的年龄相关龋齿率和潜在风险因素进行前瞻性观察研究（N=85）。使用三次样条回归模型比较 CF 参与者和 NHANES 历史对照的龋齿率。广义线性回归模型确定了 CF 中年龄和龋齿的相关因素。
结果
CF 患儿 6-9 岁的龋齿率明显低于对照组（Holm's P<0.05）。而 CF 状态在 10-20 岁之间无差异（Holm's P>0.05）。CF 患者的各种生物学/口腔内、医疗和行为因素与龋齿和年龄有关。
结论
年幼的 CF 患儿可能受到龋齿的保护，但在青春期早期，由于多种风险因素，保护作用明显丧失。需要进一步研究以证实这些发现。
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