Mahajan K K, Mahajan S K, Mishra N
Department of Physiology, Medical College, Rohtak, India.
Respiration. 1991;58(3-4):167-70. doi: 10.1159/000195920.
The lung transfer factor for carbon monoxide was studied in 24 apparently healthy smokers and in 24 well-matched non-smokers at rest and during exercise. Single-breath and steady state (TLcoss) transfer factors for carbon monoxide, the Krogh constant, and the capillary blood volume were significantly lower in smokers. Exercise increased minute ventilation to a similar extent in both groups, but significantly lower values of TLcoss were measured in smokers than in non-smokers during mild and moderate grades of exercise (p less than 0.001). This difference in TLcoss may be attributed either to the difference in capillary blood volume or to increased inhomogeneities with regard to alveolar ventilation and perfusion due to airway damages in smokers, or to both factors.
对24名看似健康的吸烟者和24名匹配良好的非吸烟者在静息状态和运动期间的一氧化碳肺转移因子进行了研究。吸烟者的一氧化碳单次呼吸和稳态（TLcoss）转移因子、克罗格常数和毛细血管血容量显著较低。两组运动均使分钟通气量增加到相似程度，但在轻度和中度运动期间，吸烟者的TLcoss值显著低于非吸烟者（p<0.001）。TLcoss的这种差异可能归因于毛细血管血容量的差异，或者归因于吸烟者气道损伤导致的肺泡通气和灌注不均匀性增加，或者归因于这两个因素。
