Bréant J, Fleury M F, van Lerberghe A, Maurique S, Frutiger F, Blin C
Rev Pneumol Clin. 1985;41(2):121-8.
During muscular exercise, the alveolo-capillary gas exchange reaches its optimal capacity, but taking blood for arterial blood gases is associated with certain risks and the classical criteria of CO transfer in the steady state are difficult to interpret as they are influenced by age, sex, ventilatory regime. The "specific" CO uptake (VCO Sp) does not correspond to these criteria (6). When related to the ERCO2, it allows the DuCO to be determined (4). It has the same value at the 3rd minute and at the 10th minute of constant exercise (5). Like TCO, it is correlated with the PaO2 during effort (5). In this study, a triangular exercise was performed by men aged between 45 add 55 years, smokers and former smokers, classified into 4 A: 12 healthy subjects; B: 56 cases of chronic respiratory disease; C: 9 cases of chronic obstructive airways disease (COAD); D: 12 cases of diffuse pulmonary fibrosis (DPF). Groups C and D were derived from group B. The VCO SP, TCO and DuCO were measured at each plateau of the triangular exercise. In the patients, the PaO2 was measured at the same time as the FF (CO, CO2). In the last phase of exercise (Ex. Max.): VCO Sp was more frequently altered at rest and more strongly correlated to TCO; TCO/V had the same significance as DuCO. The results of TCO, VCO Sp and DuCO were compared between groups A, C and D.(ABSTRACT TRUNCATED AT 250 WORDS)
在肌肉运动期间，肺泡-毛细血管气体交换达到最佳能力，但采集动脉血气样本存在一定风险，而且稳态下一氧化碳转运的经典标准难以解读，因为它们受年龄、性别、通气方式影响。“特异性”一氧化碳摄取量（VCO Sp）不符合这些标准（6）。当与呼出二氧化碳（ERCO2）相关联时，它可用于测定一氧化碳弥散量（DuCO）（4）。在持续运动的第3分钟和第10分钟，它具有相同的值（5）。与总一氧化碳含量（TCO）一样，它在运动期间与动脉血氧分压（PaO2）相关（5）。在本研究中，45至55岁的男性吸烟者和既往吸烟者进行了三角运动，分为4组：A组：12名健康受试者；B组：56例慢性呼吸道疾病患者；C组：9例慢性阻塞性气道疾病（COAD）患者；D组：12例弥漫性肺纤维化（DPF）患者。C组和D组源自B组。在三角运动的每个平台期测量VCO SP、TCO和DuCO。在患者中，与用力呼气流量（FF，一氧化碳、二氧化碳）同时测量PaO2。在运动的最后阶段（最大运动时）：VCO Sp在静息时更常发生改变，且与TCO的相关性更强；TCO/用力呼气量（V）与DuCO具有相同的意义。比较了A、C和D组之间TCO、VCO Sp和DuCO的结果。（摘要截选至250词）
