Mahajan K K, Mahajan A, Mishra N
Department of Physiology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak.
Indian J Physiol Pharmacol. 1996 Jul;40(3):267-70.
Pulmonary diffusing capacity (lung transfer factor for carbon monoxide) has been assessed by the single breath (TLCOSB) and steady state (TLCOSS) techniques in well matched 90 females, 31 non-smoker and 29 smoker males, 18-50 years of age. Both TLCOSB and TLCOSS are significantly lower in females compared to non-smoker males (P < 0.001). Tobacco smoking statistically significantly reduces TLCOSB as well as TLCOSS in smokers as compared to non-smokers. There is a statistically significant correlation of age with TLCOSS and TLCOSB in all the three groups (r = -0.702, -0.360 and 0.300 for TLCOSB and r = -0.481, -0.355 and 0.380 for TLCOSS in non-smoker males, smoker males and females respectively). TLCOSB is 30.43 +/- 4.89, 27.29 +/- 4.54 and 26.13 +/- 3.60 ml/mmHg/min, while TLCOSS is 19.47 +/- 5.26, 16.69 +/- 3.27 and 18.24 +/- 3.78 ml/mm/Hg/min in non-smoker males, smoker males and females respectively. A fairly good correlation between the TLCOSB and TLCOSS in male, both non-smoker and smoker, as well as the female subjects was observed. TLCOSS is lower than TLCOSB in all the three groups. Even in smokers of moderate intensity both of these tests are influenced to a nearly similar extent.
采用单次呼吸法（一氧化碳肺转移因子）和稳态法对90名年龄在18至50岁之间、匹配良好的女性、31名不吸烟男性和29名吸烟男性进行了肺弥散能力评估。与不吸烟男性相比，女性的单次呼吸法一氧化碳肺转移因子（TLCOSB）和稳态法一氧化碳肺转移因子（TLCOSS）均显著降低（P<0.001）。与不吸烟者相比，吸烟在统计学上显著降低了吸烟者的TLCOSB和TLCOSS。在所有三组中，年龄与TLCOSS和TLCOSB均存在统计学显著相关性（不吸烟男性、吸烟男性和女性的TLCOSB相关系数分别为r=-0.702、-0.360和0.300，TLCOSS相关系数分别为r=-0.481、-0.355和0.380）。不吸烟男性、吸烟男性和女性的TLCOSB分别为30.43±4.89、27.29±4.54和26.13±3.60 ml/mmHg/min，TLCOSS分别为19.47±5.26、16.69±3.27和18.24±3.78 ml/mm/Hg/min。在男性（包括不吸烟和吸烟男性）以及女性受试者中，观察到TLCOSB和TLCOSS之间存在相当良好的相关性。在所有三组中，TLCOSS均低于TLCOSB。即使在中度吸烟者中，这两种测试受到的影响程度也几乎相似。
