未来的药物：激素松弛素。
Drugs of the future: the hormone relaxin.
作者信息
Samuel C S, Hewitson T D, Unemori E N, Tang M L-K
机构信息
Howard Florey Institute and Department of Biochemistry & Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Cell Mol Life Sci. 2007 Jun;64(12):1539-57. doi: 10.1007/s00018-007-6543-y.
The peptide hormone relaxin is emerging as a multi-functional factor in a broad range of target tissues including several non-reproductive organs, in addition to its historical role as a hormone of pregnancy. This review discusses the evidence that collectively demonstrates the many diverse and vital roles of relaxin: the homeostatic role of endogenous relaxin in mammalian pregnancy and ageing; its gender-related effects; the therapeutic effects of relaxin in the treatment of fibrosis, inflammation, cardioprotection, vasodilation and wound healing (angiogenesis) amongst other pathophysiological conditions, and its potential mechanism of action. Furthermore, translational issues using experimental models (to humans) and its use in various clinical trials, are described, each with important lessons for the design of future trials involving relaxin. The diverse physiological and pathological roles for relaxin have led to the search for its significance in humans and highlight its potential as a drug of the future.
除了作为妊娠激素的传统作用外，肽类激素松弛素正逐渐成为包括多个非生殖器官在内的广泛靶组织中的多功能因子。本综述讨论了相关证据，这些证据共同证明了松弛素的多种重要作用：内源性松弛素在哺乳动物妊娠和衰老中的稳态作用；其与性别相关的效应；松弛素在治疗纤维化、炎症、心脏保护、血管舒张和伤口愈合（血管生成）等其他病理生理状况方面的治疗作用及其潜在作用机制。此外，还描述了使用实验模型（应用于人类）的转化问题及其在各种临床试验中的应用，每个方面都为未来涉及松弛素的试验设计提供了重要经验。松弛素多样的生理和病理作用促使人们探寻其在人类中的意义，并凸显了其作为未来药物的潜力。
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