对HIV-1 CRF07_BC gag p6序列的分析表明p6中央区域存在新的缺失。
Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6.
作者信息
Song Y H, Meng Z F, Xing H, Ruan Y H, Li X P, Xin R L, Ma P F, Peng H, Shao Y
机构信息
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, P.R. China.
出版信息
Arch Virol. 2007;152(8):1553-8. doi: 10.1007/s00705-007-0973-6. Epub 2007 Apr 26.
We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003-2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1-13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.
我们扩增了2003年至2005年期间在中国新疆地区感染HIV-1 CRF07_BC的66名个体的gag序列。在CRF07_BC gag p6结构域的中心区域检测到一种新的7个氨基酸（包括一个KELY基序）的缺失，这在其他HIV-1亚型中尚未见报道。在该结构域中还发现了多达13个氨基酸（包括KQE和KELY基序）的进一步缺失，这是迄今为止最大的自然缺失。此外，CD4 +细胞计数和病毒载量水平表明，CRF07_BC gag p6中1至13个氨基酸的缺失对病毒复制和适应性没有显著影响。
Zotero 插件