Asti M, Grassi E, Sghedoni R, De Pietri G, Fioroni F, Versari A, Borasi G, Salvo D
Nuclear Medicine Department, Santa Maria Nuova Hospital via Risorgimento 80, 42100 Reggio Emilia, Italy.
Appl Radiat Isot. 2007 Jul;65(7):831-5. doi: 10.1016/j.apradiso.2007.03.003. Epub 2007 Mar 19.
The high cost of virgin (18)O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [(18)O]H(2)O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864+/-204MBq/muA and 2727+/-167MBq/muA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2+/-0.7% to 65.5+/-0.9%, can be ascribed to the irradiation step only.
高纯度（18）O富集水的高成本迫使许多研究人员研究在首次辐照生产放射性药物后纯化和循环利用富集水的方法。在我们的研究中，[（18）O]H₂O通过臭氧分解和蒸馏进行纯化。分析表明，经过这种处理后杂质大幅减少。纯化过程是在使用GE Minitrace回旋加速器和GE Mx TracerLab合成仪生产94批[18F]-FDG之后进行的。使用原始水和再纯化水轰击后的饱和产率分别为2864±204MBq/μA和2727±167MBq/μA，下降了5.5%。[18F]-FDG产率从67.2±0.7%降至65.5±0.9%，这只能归因于辐照步骤。
