Ito Shigeki, Sakane Hitoshi, Deji Shizuhiko, Saze Takuya, Nishizawa Kunihide
Radioisotope Research Center, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
Appl Radiat Isot. 2006 Mar;64(3):298-305. doi: 10.1016/j.apradiso.2005.10.001. Epub 2005 Nov 15.
Potential radioactive byproducts in [(18)O]H(2)O irradiated with 9.6 MeV protons to produce (18)F were analyzed theoretically and experimentally. Twenty two nuclear reaction cross sections included in the National Nuclear Data Center's (NNDC) data base were selected from the possible nuclear reactions between 9.6 MeV protons and a silver havar target. Ten radionuclides: (52)Mn, (55)Fe, (55)Co, (56)Co, (57)Co, (58)Co, (59)Ni, (95)Tc, (96)Tc and (109)Cd were detected experimentally in [(18)O]H(2)O by using high purity germanium semiconductor detectors. The activities of the 10 radionuclides were distributed between 4B q and 1.2k Bq. These activities were less than the reference values given in the International Basic Safety Standards. The radionuclides derived from nuclear reactions between a silver target body and 9.6 MeV protons at a beam current 25 microA for 60 min irradiation would be exempt from restrictions for radioactive waste. The purified [(18)F]FDG prepared from (18)F produced by irradiating a silver havlar target with 9.6 MeV protons was not contaminated by the radionuclides.
对用9.6兆电子伏特质子辐照[(18)O]H(2)O以产生(18)F过程中潜在的放射性副产物进行了理论和实验分析。从9.6兆电子伏特质子与银哈瓦尔靶之间可能的核反应中，选取了美国国家核数据中心（NNDC）数据库中包含的22个核反应截面。通过使用高纯锗半导体探测器，在[(18)O]H(2)O中实验检测到了10种放射性核素：(52)Mn、(55)Fe、(55)Co、(56)Co、(57)Co、(58)Co、(59)Ni、(95)Tc、(96)Tc和(109)Cd。这10种放射性核素的活度分布在4贝克勒尔至1.2千贝克勒尔之间。这些活度低于国际基本安全标准中给出的参考值。在束流为25微安、辐照60分钟的情况下，银靶体与9.6兆电子伏特质子之间的核反应产生的放射性核素将不受放射性废物限制。用9.6兆电子伏特质子辐照银哈瓦尔靶产生的(18)F制备的纯化[(18)F]FDG未被放射性核素污染。
