Vieth R, Bayley T A, Walfish P G, Rosen I B, Pollard A
Department of Clinical Biochemistry, University of Toronto, Mount Sinai Hospital, Ontario, Canada.
Surgery. 1991 Dec;110(6):1043-6; discussion 1046-7.
We compared the relationships between 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in patients with primary hyperparathyroidism (PHPT) and 38 volunteer blood donors. There was no significant difference in mean 25(OH)D levels between patients with PHPT (34 +/- 21 nmol/L; n = 21) and the donor samples (41 +/- 19 nmol/L; n = 38). Serum 1,25(OH)2D levels were higher in the patients with PHPT compared with the donors (122 +/- 61 pmol/L vs 56 +/- 41 pmol/L; p less than 0.001). The 95th percentile 1,25(OH)2D value for the donors was exceeded in 65% of the patients with PHPT. There was a significant correlation between serum 1,25(OH)2D versus 25(OH)D in the patients with PHPT (r = 0.50; p less than 0.05) but not in the donors (r = 0.02). We conclude from the distinct elevation in 1,25(OH)2D levels in the majority of our patients with PHPT that the concentration of this parathyroid hormone-dependent hormone can be of critical value in corroborating the diagnosis of PHPT.
我们比较了原发性甲状旁腺功能亢进症（PHPT）患者与38名志愿献血者的25-羟维生素D [25(OH)D] 水平和1,25-二羟维生素D [1,25(OH)2D] 水平之间的关系。PHPT患者的平均25(OH)D水平（34±21 nmol/L；n = 21）与献血者样本（41±19 nmol/L；n = 38）之间无显著差异。与献血者相比，PHPT患者的血清1,25(OH)2D水平更高（122±61 pmol/L对56±41 pmol/L；p＜0.001）。65%的PHPT患者超过了献血者的第95百分位数1,25(OH)2D值。PHPT患者的血清1,25(OH)2D与25(OH)D之间存在显著相关性（r = 0.50；p＜0.05），而献血者中不存在这种相关性（r = 0.02）。我们从大多数PHPT患者1,25(OH)2D水平明显升高得出结论，这种甲状旁腺激素依赖性激素的浓度在确诊PHPT中可能具有关键价值。
