Corrêa André Mendes Ribeiro, Zlotowski Priscila, de Barcellos David Emilio Santos Neves, da Cruz Cláudio Estêvão Farias, Driemeier David
Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, no. 9090, 91540-000 Porto Alegre, RS, Brazil.
J Vet Diagn Invest. 2007 Jan;19(1):109-12. doi: 10.1177/104063870701900120.
Anti-porcine circovirus type 2 (anti-PCV2) immunostaining was associated with cerebellar lymphohistiocytic vasculitis combined with hemorrhages (50 pigs) or with lymphohistiocytic meningitis (23 pigs) in pigs naturally affected with postweaning multisystemic wasting syndrome (PMWS). The animals originated from 12 farms in Rio Grande do Sul, Brazil. In total, 456 unthrifty 3- to 5-month-old postweaning pigs confirmed as PMWS cases were necropsied. Although most findings mimicked those extensively reported in PMWS-affected pigs, there were distinctive brain lesions that included multiple hemorrhages in the cerebellar leptomeninges associated with lymphohistiocytic vasculitis and fibrinoid degeneration in vessels of the cerebellum and periventricular areas (69 pigs). These vascular lesions were also seen in conjunction with lymphohistiocytic meningitis (38 additional pigs). PCV2 antigen was immunohistochemically demonstrated in the cytoplasm and nuclei from intralesional perivascular macrophages and endothelial-like cells in brain tissues. Together these findings suggest that these lesions were caused by PCV2.
在自然感染断奶后多系统消耗综合征（PMWS）的猪中，抗猪圆环病毒2型（抗PCV2）免疫染色与小脑淋巴细胞性血管炎合并出血（50头猪）或淋巴细胞性脑膜炎（23头猪）有关。这些动物来自巴西南里奥格兰德州的12个农场。总共对456头3至5月龄、被确诊为PMWS病例的发育不良断奶后仔猪进行了尸检。尽管大多数发现与PMWS感染猪中广泛报道的情况相似，但存在独特的脑部病变，包括小脑软脑膜多处出血，伴有淋巴细胞性血管炎以及小脑和脑室周围区域血管的纤维蛋白样变性（69头猪）。这些血管病变还与淋巴细胞性脑膜炎同时出现（另外38头猪）。通过免疫组织化学方法在脑组织内病变血管周围的巨噬细胞和内皮样细胞的细胞质及细胞核中证实了PCV2抗原的存在。这些发现共同表明这些病变是由PCV2引起的。
