Yoon Chang Kyoon, Kyoung Seung Eun, Chang Moo Hwan
Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea.
Korean J Ophthalmol. 2007 Mar;21(1):55-60. doi: 10.3341/kjo.2007.21.1.55.
To evaluate the diode laser photodynamic therapy efficacy on choroidal neovascularization (CNV) in the treatment of three patients with age-related macular degeneration (ARMD).
The authors selected three patients with ARMD whose vision has decreased due to CNV, and applied diode laser treatment after injecting an indocyanine green (ICG) solution. The patients were followed for at least three months after treatment, and examinations included evaluating vision changes and possible leakage on fluorescein angiography (FAG).
The final vision of two patients improved by more than one line on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart after at least three months of follow-up. However, the final vision of the third patient decreased by one line on ETDRS chart. FAG was done in all patients, and in two of the patients, there was no evidence of leakage at the laser-applied site. In the other patient, there was evidence of minimal leakage, with the area of leakage decreasing by more than fifty percent. Side effects of ICG were not found during or after the photodynamic therapy sessions.
The photodynamic usage of ICG treatment of CNV in patients with ARMD, was effective in preventing or improving the visual outcome. Compared to the widely used verteporfin, ICG is more stable and is more cost effective. The authors therefore came to a conclusion that ICG can be very useful in the treatment of CNV. However, further studies are necessary.
评估二极管激光光动力疗法对三名年龄相关性黄斑变性（ARMD）患者脉络膜新生血管（CNV）的治疗效果。
作者选取了三名因CNV导致视力下降的ARMD患者，在注射吲哚菁绿（ICG）溶液后进行二极管激光治疗。治疗后对患者进行至少三个月的随访，检查包括评估视力变化以及荧光素血管造影（FAG）中是否可能存在渗漏。
至少随访三个月后，两名患者在早期糖尿病视网膜病变研究（ETDRS）视力表上的最终视力提高了一行以上。然而，第三名患者在ETDRS视力表上的最终视力下降了一行。所有患者均进行了FAG检查，其中两名患者在激光照射部位没有渗漏迹象。另一名患者有轻微渗漏迹象，渗漏面积减少了超过50%。在光动力治疗期间及之后未发现ICG的副作用。
ICG光动力疗法治疗ARMD患者的CNV，在预防或改善视力结果方面是有效的。与广泛使用的维替泊芬相比，ICG更稳定且更具成本效益。因此，作者得出结论，ICG在治疗CNV方面可能非常有用。然而，还需要进一步研究。
