Arnold E K, Beasley V R, Parker A J, Stedelin J R
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Vet Hum Toxicol. 1991 Oct;33(5):446-9.
English pointer dogs dosed po with encapsulated 2,4-dichlorophenoxyacetic acid (2,4-D) at 1.3, 8.8, 43.7, 175 or 220 mg/kg body weight failed to exhibit abnormalities in hematologic, serum biochemical, urinalysis, or electrocardiographic parameters. At the 3 lowest doses, no changes were noted in electro-encephalograms (EEGs). In the dog given 175 mg/kg, at 24 h postdosing mild sedation was accompanied by excessive slowing in the EEG with loss of low voltage fast activity. In the dog given 220 mg/kg, nonspecific alterations in the EEG suggestive of irritation and mild seizure activity was detected 7 h, but the EEG returned to normal by 24 h. A maximum 2,4-D concentration in serum of 1075 ppm was detected 5 h after a po dose of 220 mg/kg. A maximum 2,4-D, concentration in urine of 1792 ppm was detected 2 h after a po dose of 175 mg/kg, while 25 h after that dose kidney issue contained 271 ppm.
给英国指示犬经口灌胃给予包封的2,4-二氯苯氧基乙酸（2,4-D），剂量分别为1.3、8.8、43.7、175或220mg/kg体重，结果这些犬在血液学、血清生化、尿液分析或心电图参数方面均未出现异常。在3个最低剂量组中，脑电图（EEG）未发现变化。给予175mg/kg的犬，给药后24小时出现轻度镇静，同时脑电图过度减慢，低电压快活动消失。给予220mg/kg的犬，给药后7小时检测到脑电图有提示刺激和轻度癫痫活动的非特异性改变，但脑电图在24小时时恢复正常。经口给予220mg/kg剂量后5小时，血清中2,4-D的最大浓度为1075ppm。经口给予175mg/kg剂量后2小时，尿液中2,4-D的最大浓度为1792ppm，而该剂量给药后25小时，肾脏组织中含有271ppm。
