Fukatsu Y, Miyake Y, Sugita S, Watanabe S
Eye Clinic, Toyota Memorial Hospital, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Oct;95(10):973-85.
To analyze the electrically evoked response (EER) in relation to the central visual pathway, the response characteristics of the lateral geniculate neurons (LGNs) of the EER in 35 anesthetized adult cats were studied. Responses of the LGNs showed interindividual variation of more than one log unit in terms of the stimulus threshold for electrical stimuli. As the stimulus intensity increased, the spikes with constant latencies were recorded, which showed bursts with much stronger stimuli. The latencies of the spikes were closely correlated with those of negative components of EER. The LGNs were divided into two major groups by the latency. The periodical and alternative excitation of these neurons contributed to form the first negative wave of EER. The latency of these two major groups of LGNs was reversed when the electrode polarity was changed. At higher stimulus intensities, the components with short latency became dominant and those with longer latency were suppressed. The above results suggested that the periodical excitation of LGNs and the formation of the prominent EER components may result from the interaction between on- and off-type retinal ganglion cells and amacrine cells. It was also suggested that the origins of the wavelets in negative waves of EER at strong stimuli are the bursts of the spikes of the visual cortex neurons.
为了分析与中枢视觉通路相关的电诱发反应（EER），研究了35只麻醉成年猫的EER中外侧膝状核神经元（LGNs）的反应特征。LGNs的反应在电刺激的刺激阈值方面表现出超过一个对数单位的个体间差异。随着刺激强度增加，记录到潜伏期恒定的尖峰，在更强刺激时出现爆发。尖峰的潜伏期与EER负成分的潜伏期密切相关。根据潜伏期，LGNs被分为两大组。这些神经元的周期性和交替性兴奋有助于形成EER的第一个负波。当电极极性改变时，这两大组LGNs的潜伏期会反转。在更高刺激强度下，潜伏期短的成分占主导，潜伏期长的成分受到抑制。上述结果表明，LGNs的周期性兴奋和突出的EER成分的形成可能源于on型和off型视网膜神经节细胞与无长突细胞之间的相互作用。还表明，强刺激下EER负波中小波的起源是视觉皮层神经元尖峰的爆发。
