Seo Dong Beom, Kwon Kye Sook, Park Hyun Shin, Lee Don Haeng, Kim Hyung Gil, Shin Yong Woon, Kim Young Soo, Kim Joon Mi
Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
Korean J Gastroenterol. 2007 Apr;49(4):245-50.
Metachronous association between gastric lymphoma and early gastric cancer is a rare event. Recent studies have suggested that a relationship exists between gastric mucosa-associated lymphoid tissue (MALT) lymphoma and gastric carcinoma although the mechanism is unknown. Herein, we report a 53-year-old man who visited to our hospital due to melena. Esophagogastroduodenoscopy (EGD) revealed a MALT lymphoma on the greater curvature of lower body. The patient received anti-Helicobacter pylori eradication therapy, followed by 6 cycles of chemotherapy and radiation therapy, and achieved complete remission 12 months after the therapy. Three years later, he revisited our hospital with epigastric pain. EGD revealed an early gastric cancer on the anterior wall of proximal antrum, nearly opposite to the previous lymphoma site, and a partial gastrectomy was performed. To the best of our knowledge, this is the first case report of metachronous MALT lymphoma and subsequent gastric carcinoma in Korea.
胃淋巴瘤与早期胃癌的异时性关联是一种罕见事件。近期研究表明，胃黏膜相关淋巴组织（MALT）淋巴瘤与胃癌之间存在关联，尽管其机制尚不清楚。在此，我们报告一名53岁男性，因黑便前来我院就诊。食管胃十二指肠镜检查（EGD）显示胃体下部大弯处有一处MALT淋巴瘤。该患者接受了抗幽门螺杆菌根除治疗，随后进行了6个周期的化疗和放疗，并在治疗后12个月实现完全缓解。三年后，他因上腹部疼痛再次来我院就诊。EGD显示胃窦近端前壁有早期胃癌，几乎与先前淋巴瘤部位相对，遂行部分胃切除术。据我们所知，这是韩国首例关于异时性MALT淋巴瘤及随后发生胃癌的病例报告。
