Ferreira António Carlos, Isomoto Hajime, Moriyama Masatsugu, Fujioka Toshio, Machado José Carlos, Yamaoka Yoshio
IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.
Helicobacter. 2008 Oct;13 Suppl 1(Suppl 1):28-34. doi: 10.1111/j.1523-5378.2008.00633.x.
Individuals infected with Helicobacter pylori, a stomach colonizing bacteria, have an increased risk of developing gastric malignancies. The risk for developing cancer relates to the physiologic and histologic changes that H. pylori infection induces in the stomach. In the last year numerous studies have been conducted in order to characterize the association between H. pylori infection and gastric cancer. These studies range from epidemiologic approaches aiming at the identification of environmental, host genetic, and bacterial factors associated with risk of gastric cancer, to molecular and cell biology approaches aiming at understanding the interaction between H. pylori and the transforming epithelial cell. In this review an account of the last year's research activity on the relationship between H. pylori and gastric cancer will be given.
感染幽门螺杆菌(一种寄生于胃部的细菌)的个体患胃部恶性肿瘤的风险会增加。患癌风险与幽门螺杆菌感染在胃中引发的生理和组织学变化有关。去年开展了大量研究,旨在明确幽门螺杆菌感染与胃癌之间的关联。这些研究涵盖了多种方法,从旨在识别与胃癌风险相关的环境、宿主基因和细菌因素的流行病学方法,到旨在理解幽门螺杆菌与转化上皮细胞之间相互作用的分子和细胞生物学方法。在这篇综述中,将介绍去年关于幽门螺杆菌与胃癌关系的研究活动。