Wu Jian, Oka Jun, Ezaki Junko, Ohtomo Takuya, Ueno Tomomi, Uchiyama Shigeto, Toda Toshiya, Uehara Mariko, Ishimi Yoshiko
Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan.
Menopause. 2007 Sep-Oct;14(5):866-74. doi: 10.1097/gme.0b013e3180305299.
Equol is more biologically active than its precursor daidzein, which is the principal isoflavone found in soybean. There are interindividual differences in the ability to produce equol; these may lead to differences in the effects of isoflavone intervention on human health. This study aimed to investigate whether the effects of soy isoflavones on bone and fat mass are related to an individual's equol status.
We performed a 1-year double-blind, randomized trial to compare the effects of isoflavone (75 mg of isoflavone conjugates/day) with those of placebo on bone mineral density, fat mass, and serum isoflavone concentrations in early postmenopausal Japanese women who were classified based on their equol-producer phenotype.
After 1 year, the isoflavone intervention significantly increased the serum equol concentration in the equol producers but not in the nonproducers. In the isoflavone group, the annualized changes in the bone mineral density of the total hip and intertrochanteric regions were -0.46% and -0.04%, respectively, in the equol producers and -2.28% and -2.61%, respectively, in the nonproducers; these values were significantly different (P<0.05 for both the regions). Significant differences were observed between the equol producers and nonproducers in the isoflavone group with regard to the annualized changes in the fat mass. No significant difference in the annualized changes in bone mineral density and fat mass was observed between the equol producers and nonproducers in the placebo group.
Our data suggest that the preventive effects of isoflavones on bone loss and fat accumulation in early postmenopausal women depend on an individual's equol-producing capacity.
雌马酚比其前体黄豆苷元具有更强的生物活性，黄豆苷元是大豆中主要的异黄酮。个体产生雌马酚的能力存在差异；这些差异可能导致异黄酮干预对人类健康的影响有所不同。本研究旨在调查大豆异黄酮对骨骼和脂肪量的影响是否与个体的雌马酚状态有关。
我们进行了一项为期1年的双盲随机试验，比较异黄酮（75毫克异黄酮共轭物/天）与安慰剂对绝经后早期日本女性骨矿物质密度、脂肪量和血清异黄酮浓度的影响，这些女性根据其雌马酚产生者表型进行分类。
1年后，异黄酮干预使雌马酚产生者的血清雌马酚浓度显著升高，但对非产生者无此作用。在异黄酮组中，雌马酚产生者全髋和转子间区域的骨矿物质密度年化变化分别为-0.46%和-0.04%，非产生者分别为-2. .28%和-2.61%；这两个区域的值均有显著差异（两个区域P<0.05）。在异黄酮组中，雌马酚产生者和非产生者在脂肪量年化变化方面存在显著差异。在安慰剂组中，雌马酚产生者和非产生者在骨矿物质密度和脂肪量年化变化方面未观察到显著差异。
我们的数据表明，异黄酮对绝经后早期女性骨质流失和脂肪堆积的预防作用取决于个体产生雌马酚的能力。
