医学成像中的镓-68

Gallium-68 in Medical Imaging.

作者信息

Martiniova Lucia, Palatis Louis De, Etchebehere Elba, Ravizzini Gregory

机构信息

University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit Number: 1483, Houston, TX 7703, USA.

出版信息

Curr Radiopharm. 2016;9(3):187-207. doi: 10.2174/1874471009666161028150654.

DOI:10.2174/1874471009666161028150654

PMID:27804868

Abstract

Over the past several years, Positron Emission Tomography (PET) imaging agents labeled with ;68Gallium (68Ga) have undergone a significant increase in clinical utilization. 68Ga is conveniently produced from a germanium-68/gallium-68 (68Ge/68Ga) generator. Because of the compact size and ease of use of the generator, 68Ga labeled compounds may be more cost-effective than PET radioisotopes that are cyclotron-produced. The convenient half-life of 68Ga (T1/2=68 min) provides sufficient radioactivity for various PET imaging applications, while delivering acceptable radiation doses to patients. This chapter summarizes the emerging clinical utilization of 68Ga-based radiotracers in medical imaging.

摘要

在过去几年中，标记有镓-68（68Ga）的正电子发射断层扫描（PET）显像剂的临床应用显著增加。68Ga可方便地从锗-68/镓-68（68Ge/68Ga）发生器中产生。由于发生器体积小巧且使用方便，与回旋加速器生产的PET放射性同位素相比，68Ga标记的化合物可能更具成本效益。68Ga方便的半衰期（T1/2 = 68分钟）为各种PET成像应用提供了足够的放射性，同时给患者带来可接受的辐射剂量。本章总结了基于68Ga的放射性示踪剂在医学成像中新兴的临床应用。