Quaranta V, Manenti G, Bolacchi F, Cossu E, Pistolese C A, Buonomo O C, Carotenuto L, Piconi C, Simonetti G
1Tecnobiomedica S.p.A. Via Vaccareccia 41, 00040 Pomezia, Rome, Italy.
Anticancer Res. 2007 Mar-Apr;27(2):775-84.
Radio-frequency ablation (RFA) has recently received much attention as an effective minimally invasive strategy for the local treatment of tumors. The purpose of this study was to evaluate the efficacy of single-needle cool-tip RF breast ablation in terms of temperature distribution and duration of the procedure as compared to multiprobe RF breast ablation.
Two different commercially available radiofrequency ablation needle electrodes were compared. Finite-element method (FEM) models were developed to simulate the thermoablation procedures. A series of ex vivo radiofrequency thermal lesions were induced to check the response of the FEM calculations.
Data obtained from FEM models and from ex vivo procedures showed that cool-tip RF breast ablation assures better performances than multiprobe RF breast ablation in terms of temperature distribution and duration of the procedure. Histopathological analysis of the cool-tip RF thermoablated specimens showed successful induction of coagulation necrosis in the thermoablated specimens.
Data obtained from FEM models and from ex vivo procedures suggest that the proposed cool-tip RF breast ablation may kill more tumor cells in vivo with a single application than the multiprobe RF breast ablation.
射频消融术（RFA）作为一种有效的肿瘤局部微创治疗策略，近来备受关注。本研究旨在对比单针冷循环射频乳腺消融术与多探头射频乳腺消融术在温度分布及手术持续时间方面的疗效。
比较了两种不同的市售射频消融针电极。构建了有限元方法（FEM）模型以模拟热消融过程。进行了一系列体外射频热损伤实验，以检验有限元计算结果。
有限元模型及体外实验获得的数据表明，在温度分布及手术持续时间方面，冷循环射频乳腺消融术比多探头射频乳腺消融术具有更好的表现。对冷循环射频热消融标本的组织病理学分析显示，热消融标本成功诱导了凝固性坏死。
有限元模型及体外实验获得的数据表明，与多探头射频乳腺消融术相比，所提出的冷循环射频乳腺消融术单次应用可能在体内杀死更多肿瘤细胞。
