Blandamura Stella, D'Alessandro Emiliano, Guzzardo Vincenza, Giacomelli Luciano, Moschino Paolo, Parenti Anna, Ninfo Vito
Section of Pathological Anatomy, Department of Medico-Diagnostic Sciences and Special Therapies, University of Padova, Via Gabelli 61, 35121 Padova, Italy.
Anticancer Res. 2007 Mar-Apr;27(2):1059-65.
Maspin is a unique serine proteinase inhibitor which has tumor suppressor activity. The aim of the present study was to investigate the role of maspin in ampullary adenocarcinomas, its correlation with apoptosis and its value as a prognostic marker.
Twenty-three cases of ampulla of Vater adenocarcinoma were collected from archival material. For each sample, maspin, M30, p53 and Mib1 immunohistochemical reactivity were evaluated and results compared with clinicopathological parameters.
A statistical relation was found between nuclear maspin and M30 (Spearman's Q = 0.46, p = 0.02), and p53 (Kruskal-Wallis = 0.03); a trend was found between nuclear maspin and pT (Kruskal-Wallis = 0.09), and pM (Mann-Whitney = 0.08) and pN status (Fisher's mid-point test: p = 0.070).
The present study evaluated the role of maspin in ampullary adenocarcinomas and for the first time demonstrated its association with apoptosis, tumor growth and metastasis.
Maspin是一种具有肿瘤抑制活性的独特丝氨酸蛋白酶抑制剂。本研究旨在探讨Maspin在壶腹腺癌中的作用、其与细胞凋亡的相关性及其作为预后标志物的价值。
从存档材料中收集23例 Vater壶腹腺癌病例。对每个样本评估Maspin、M30、p53和Mib1的免疫组化反应性，并将结果与临床病理参数进行比较。
发现核Maspin与M30之间存在统计学关系（Spearman's Q = 0.46，p = 0.02），与p53之间也存在统计学关系（Kruskal-Wallis = 0.03）；在核Maspin与pT之间发现一种趋势（Kruskal-Wallis = 0.09），与pM之间也存在趋势（Mann-Whitney = 0.08）以及与pN状态之间存在趋势（Fisher中点检验：p = 0.070）。
本研究评估了Maspin在壶腹腺癌中的作用，并首次证明了其与细胞凋亡、肿瘤生长和转移的关联。
