Kim Su Jin, Lee Hyoun Wook, Kim Dae Cheol, Rha Seo Hee, Hong Sook Hee, Jeong Jin Sook
Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
Pathol Int. 2008 Apr;58(4):233-8. doi: 10.1111/j.1440-1827.2008.02216.x.
The expression of glucose transporter protein 1 (GLUT1) in malignant tumors is increased due to the higher metabolic needs of the proliferating cell populations. Aberrant GLUT1 expression is exhibited in a wide spectrum of epithelial malignancies and their precursors, which occur with low frequency and intensity; aberrant GLUT1 expression does not occur in normal epithelial cells. The expression of GLUT1 in tumors of the ampulla of Vater was evaluated on immunohistochemistry, and the relationships of GLUT1 expression to histological parameters and p53 expression were analyzed. Twenty-one (58.3%) of 36 adenocarcinomas and three (17.6%) of 17 adenomas had GLUT1 immunoreactivity. None of the regenerating or normal epithelia had any immunoreactivity. No significant relationships were found between GLUT1 expression and histological parameters or p53 expression. It was found that histological subtypes originated from different epithelium were strongly related to different macroscopic types. In the ampulla of Vater, GLUT1 expression was associated with malignant change, and might be a useful marker of malignancy.
由于增殖细胞群体对代谢的更高需求，恶性肿瘤中葡萄糖转运蛋白1（GLUT1）的表达增加。GLUT1异常表达出现在多种上皮性恶性肿瘤及其前驱病变中，其出现频率和强度较低；正常上皮细胞中不出现GLUT1异常表达。采用免疫组织化学方法评估了Vater壶腹肿瘤中GLUT1的表达，并分析了GLUT1表达与组织学参数及p53表达的关系。36例腺癌中有21例（58.3%）、17例腺瘤中有3例（17.6%）有GLUT1免疫反应性。再生上皮或正常上皮均无免疫反应性。未发现GLUT1表达与组织学参数或p53表达之间存在显著关系。发现起源于不同上皮的组织学亚型与不同的大体类型密切相关。在Vater壶腹中，GLUT1表达与恶性改变相关，可能是一种有用的恶性肿瘤标志物。
