Leach J Kent
Department of Biomedical Engineering, University of California, Davis, 451 East Health Sciences Drive, Davis, CA 95616, USA.
Regen Med. 2006 Jul;1(4):447-55. doi: 10.2217/17460751.1.4.447.
Current approaches in tissue engineering and regenerative medicine have focused on controlling the presentation of various factors that influence cellular behavior and tissue formation. Numerous biomaterials have been utilized as sites for new tissue growth by migrating or transplanted cells, nanoscale control of cellular behavior through the presentation of specific peptide sequences, and depots for growth factor release. More recently, the development of bioresponsive materials has emerged as a promising approach to cede control of temporal macromolecule presentation and material degradation to invading cell populations. Biomaterials now have the potential of possessing multiple functions in the process of tissue regeneration. This review summarizes some of the recent advances in the use of multifunctional biomaterials in the arena of tissue engineering. Specifically, the potential of various materials is described as it pertains to the control of cellular behavior, integration of engineered materials with host or transplanted tissue, and inductive factor presentation.
组织工程和再生医学的当前方法聚焦于控制影响细胞行为和组织形成的各种因素的呈现。众多生物材料已被用作新组织生长的场所，供迁移或移植的细胞生长，通过呈现特定肽序列对细胞行为进行纳米级控制，以及作为生长因子释放的储存库。最近，生物响应性材料的发展已成为一种有前景的方法，可将对大分子呈现时间和材料降解的控制让渡给侵入的细胞群体。生物材料现在在组织再生过程中具有发挥多种功能的潜力。本综述总结了多功能生物材料在组织工程领域应用的一些最新进展。具体而言，描述了各种材料在控制细胞行为、工程材料与宿主或移植组织的整合以及诱导因子呈现方面的潜力。
