Srouji Samer, Kizhner Tali, Livne Erella
Anatomy and Cell Biology Department, Faculty of Medicine, Technion, Haifa, Israel.
Regen Med. 2006 Jul;1(4):519-28. doi: 10.2217/17460751.1.4.519.
Bone tissue repair is one of the major concerns of regenerative medicine. The current need for tissue replacements has necessitated the development of a new science termed 'bone tissue engineering'. The basic organization of bone tissue requires the design and fabrication of a porous 3D structure or 'scaffold' to contain the bone-forming cells. This scaffold should be formulated from biocompatible, osteoconductive materials that are not immunoreactive. 3D scaffolds provide the necessary support for cells to proliferate and maintain their capacity to differentiate and scaffolds containing bone marrow-derived osteoprogenitors can be employed within implants to enhance bone repair. The complex construct is intended to mimic the native in vivo microenvironment and this demands construction of bioactive scaffolds that are also capable of supporting vascularization as well as cell proliferation and osteogenic differentiation. 3D bioactive scaffolds containing committed osteoprogenitors can provide a promising surgical tool for bone tissue engineering directed at orthopedic and cranio-maxillofacial clinical applications.
骨组织修复是再生医学的主要关注点之一。当前对组织替代物的需求促使了一门名为“骨组织工程”的新科学的发展。骨组织的基本结构需要设计和制造一种多孔三维结构或“支架”来容纳成骨细胞。这种支架应由生物相容性、骨传导性且无免疫反应性的材料制成。三维支架为细胞增殖以及维持其分化能力提供了必要的支撑，并且含有骨髓来源的骨祖细胞的支架可用于植入物中以增强骨修复。这种复杂的构建体旨在模拟体内天然微环境，这就要求构建具有生物活性的支架，该支架还能够支持血管生成以及细胞增殖和成骨分化。含有定向骨祖细胞的三维生物活性支架可为针对骨科和颅颌面临床应用的骨组织工程提供一种有前景的手术工具。
