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接种于肽水凝胶上的人骨髓间充质干细胞移植可减少牙槽骨吸收。

Transplanted Human Bone Marrow Mesenchymal Stem Cells Seeded onto Peptide Hydrogel Decrease Alveolar Bone Loss.

作者信息

Tcacencu Ion, Karlström Erik, Cedervall Jessica, Wendel Mikael

机构信息

Department of Dental Medicine, Karolinska Institutet , Huddinge, Sweden .

出版信息

Biores Open Access. 2012 Oct;1(5):215-21. doi: 10.1089/biores.2012.0239.

DOI:10.1089/biores.2012.0239
PMID:23514848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3559219/
Abstract

Alveolar bone loss can be caused by periodontitis or periodontal trauma. We have evaluated the effects of transplanted undifferentiated human mesenchymal stem cells (hMSCs) on alveolar bone reaction and periodontal ligament healing in an experimental periodontal wound model. The hMSCs seeded onto a self-assembling peptide hydrogel in combination with collagen sponge were implanted into the right mandible of 12 rats and followed for 1 (n=6) or 4 weeks (n=6) postoperatively. The other 12 sham-treated rats were used as controls. Histological and histomorphometrical methods were used to assess the periodontal tissue reaction. The alveolar bone volume density was significantly higher at 1 week after surgery, and the osteoclast number was significantly lower at both 1 week and 4 weeks postoperatively in the mandibles treated with hMSCs. The implanted cells were detected only at 1 week after surgery. In conclusion, transplanted hMSCs can contribute to alveolar bone preservation after a periodontal surgical trauma at least by decreasing local osteoclast number.

摘要

牙槽骨丧失可由牙周炎或牙周创伤引起。我们在实验性牙周伤口模型中评估了移植的未分化人骨髓间充质干细胞（hMSCs）对牙槽骨反应和牙周韧带愈合的影响。将接种于自组装肽水凝胶并结合胶原海绵的hMSCs植入12只大鼠的右下颌骨，并在术后1周（n = 6）或4周（n = 6）进行随访。另外12只假处理大鼠用作对照。采用组织学和组织形态计量学方法评估牙周组织反应。在接受hMSCs治疗的下颌骨中，术后1周牙槽骨体积密度显著更高，术后1周和4周破骨细胞数量均显著更低。仅在术后1周检测到植入细胞。总之，移植的hMSCs至少通过减少局部破骨细胞数量，有助于牙周手术创伤后牙槽骨的保存。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/fc5075d9aa96/fig-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/71f4d4f22085/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/b2b76bc72b6c/fig-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/82a94e9bd230/fig-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/7fe7d440622b/fig-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/9e6dab16f7c6/fig-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/d7964c474a2e/fig-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/00635f6847dd/fig-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/fc5075d9aa96/fig-8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/71f4d4f22085/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/b2b76bc72b6c/fig-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/82a94e9bd230/fig-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/7fe7d440622b/fig-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/9e6dab16f7c6/fig-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/d7964c474a2e/fig-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/00635f6847dd/fig-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/3559219/fc5075d9aa96/fig-8.jpg

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Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile.鼠骨髓间充质基质细胞将活化的巨噬细胞转化为具有调节表型的细胞。
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Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.
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