Fernell Elisabeth, Fagerberg Ulrika L, Hellström Per M
Department of Neuropaediatrics, Astrid Lindgren Children's Hospital, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
Acta Paediatr. 2007 Jul;96(7):1076-9. doi: 10.1111/j.1651-2227.2007.00298.x. Epub 2007 Apr 27.
Due to parental concern regarding the child's bowel habits and the ongoing discussion whether there might be an association between autism and intestinal inflammation, two inflammatory markers were analysed in a group of children with autism.
Twenty-four consecutive children with autism (3-13 years) of unknown aetiology were investigated with respect to faecal calprotectin and rectal nitric oxide (NO).
One child who previously had a severe Clostridium difficile infection displayed raised levels of both these inflammatory markers and one child with extreme constipation for whom only calprotectin was possible to measure had raised levels. The remaining children displayed results that did not indicate an active inflammatory status in the intestine when the two inflammatory markers were combined.
By the use of two independent markers of inflammatory reactions in the gut, i.e. rectal NO and faecal calprotectin we were not able to disclose evidence of a link between the autistic disorder and active intestinal inflammation.
由于家长对孩子肠道习惯的关注，以及关于自闭症与肠道炎症之间是否可能存在关联的持续讨论，对一组自闭症儿童的两种炎症标志物进行了分析。
对24名病因不明的连续自闭症儿童（3至13岁）进行了粪便钙卫蛋白和直肠一氧化氮（NO）的检测。
一名曾患有严重艰难梭菌感染的儿童这两种炎症标志物水平均升高，一名严重便秘且仅能检测钙卫蛋白的儿童其钙卫蛋白水平升高。当将这两种炎症标志物结合起来看时，其余儿童的检测结果并未显示肠道存在活跃的炎症状态。
通过使用两种肠道炎症反应的独立标志物，即直肠NO和粪便钙卫蛋白，我们未能发现自闭症谱系障碍与活跃肠道炎症之间存在关联的证据。
