Ordookhani Arash, Pearce Elizabeth N, Hedayati Mehdi, Mirmiran Parvin, Salimi Sanam, Azizi Fereidoun, Braverman Lewis E
Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Clin Endocrinol (Oxf). 2007 Aug;67(2):175-9. doi: 10.1111/j.1365-2265.2007.02857.x. Epub 2007 Apr 27.
To measure breast milk iodine (MI) and urinary iodine (UI) concentrations in healthy newborns and their nursing mothers from an iodine-sufficient region to determine adequacy and to relate these parameters to thyroid function tests in mothers and infants.
Cross-sectional.
Forty-eight healthy neonates of 37 to 42 weeks' gestation with normal cord blood TSH values and their mothers were recruited in Tehran, Iran.
Serum thyroid function tests were performed, and maternal and infant urinary iodine excretion, and maternal MI concentration were measured.
Neonatal age was 12.9 +/- 3.9 (mean +/- SD; range 7-30) days and maternal age was 25.8 +/- 5 years. Median (range) UI in neonates was 271 microg/l (57-800) and in mothers was 107 microg/l (20-710). Median (range) MI was 148 microg/l (45-750). Neonatal and maternal UI did not correlate with serum thyroid function tests. UI < 150, 150-230, and > 230 microg/l was found in 20, 12.5, and 67.5% of neonates and 79.1, 14, and 7% of mothers, respectively. MI was < 150, 150-180, and > 180 microg/l in 52.4, 11.9, and 35.7% of mothers, respectively.
Among euthyroid neonates, UI was adequate despite low median maternal UI and MI concentrations. There were no significant correlations between UI or MI and thyroid function tests in the mothers and infants.
测量来自碘充足地区的健康新生儿及其哺乳母亲的母乳碘（MI）和尿碘（UI）浓度，以确定其充足程度，并将这些参数与母亲和婴儿的甲状腺功能测试相关联。
横断面研究。
在伊朗德黑兰招募了48名妊娠37至42周、脐血促甲状腺激素（TSH）值正常的健康新生儿及其母亲。
进行血清甲状腺功能测试，并测量母婴尿碘排泄和母亲的MI浓度。
新生儿年龄为12.9±3.9（平均±标准差；范围7 - 30）天，母亲年龄为25.8±5岁。新生儿尿碘中位数（范围）为271微克/升（57 - 800），母亲为107微克/升（20 - 710）。母乳碘中位数（范围）为148微克/升（45 - 750）。新生儿和母亲的尿碘与血清甲状腺功能测试无相关性。尿碘<150微克/升、150 - 230微克/升和>230微克/升的新生儿分别占20%、12.5%和67.5%，母亲分别占79.1%、14%和7%。母亲的母乳碘<150微克/升、150 - 180微克/升和>180微克/升的分别占52.4%、11.9%和35.7%。
在甲状腺功能正常的新生儿中，尽管母亲尿碘和母乳碘浓度中位数较低，但尿碘充足。母婴的尿碘或母乳碘与甲状腺功能测试之间无显著相关性。
