血小板磷脂n-3多不饱和脂肪酸与中老年高脂血症患者血浆同型半胱氨酸呈负相关。

Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients.

作者信息

Li D, Yu X M, Xie H B, Zhang Y H, Wang Q, Zhou X Q, Yu P, Wang L J

机构信息

Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou, Zhejiang 310029, China.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):293-7. doi: 10.1016/j.plefa.2007.02.003. Epub 2007 Apr 26.

DOI:10.1016/j.plefa.2007.02.003

PMID:17466498

Abstract

Studies showed that increased dietary intake of n-3 polyunsaturated fatty acids (PUFA) has a cardiovascular beneficial effect. Increased plasma phospholipid (PL) docosahexaenoic acid (22:6n-3) is associated with decreased plasma homocysteine (Hcy). The aim of this study was to investigate the relationship between platelet PL fatty acid and plasma Hcy in middle-aged and geriatric hyperlipaemia patients (50 males, 31 females) and 65 healthy subjects (43 males, 22 females) in Hangzhou, China. Plasma Hcy demonstrated significant positive correlation with adrenic acid (22:4n-6) (r = 0.188, P = 0.018) and negative correlation with 22:6n-3 (r = -0.277, P = 0.001) and the ratio of n-3/n-6 (r = -0.231, P = 0.003) in sex-, age- and BMI-controlled partial correlation analysis. The present results suggest that increased ratio of n-3/n-6 PUFA in platelet PL is associated with decreased thrombotic risks such as plasma Hcy in middle-aged and geriatric hyperlipaemia patients in Hangzhou.

摘要

研究表明，增加膳食中n-3多不饱和脂肪酸（PUFA）的摄入量具有心血管有益作用。血浆磷脂（PL）中二十二碳六烯酸（22:6n-3）增加与血浆同型半胱氨酸（Hcy）降低相关。本研究旨在调查中国杭州中老年高脂血症患者（50名男性，31名女性）和65名健康受试者（43名男性，22名女性）血小板PL脂肪酸与血浆Hcy之间的关系。在进行性别、年龄和体重指数控制的偏相关分析中，血浆Hcy与肾上腺酸（22:4n-6）呈显著正相关（r = 0.188，P = 0.018），与22:6n-3呈负相关（r = -0.277，P = 0.001），与n-3/n-6比值呈负相关（r = -0.231，P = 0.003）。目前的结果表明，血小板PL中n-3/n-6 PUFA比值增加与杭州中老年高脂血症患者血浆Hcy等血栓形成风险降低相关。