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多不饱和脂肪酸通过调节参与蛋氨酸代谢的基因表达对同型半胱氨酸代谢的影响。

Effect of polyunsaturated fatty acids on homocysteine metabolism through regulating the gene expressions involved in methionine metabolism.

作者信息

Huang Tao, Hu Xiaojie, Khan Nicholas, Yang Jing, Li Duo

机构信息

Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310059, China.

出版信息

ScientificWorldJournal. 2013 May 23;2013:931626. doi: 10.1155/2013/931626. Print 2013.

DOI:10.1155/2013/931626
PMID:23766724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3676954/
Abstract

The objective was to investigate the regulatory effect of polyunsaturated fatty acids (PUFAs) on mRNA expression of key genes involved in homocysteine (Hcy) metabolism. Eighty male Sprague Dawley rats were randomly divided into eight groups. The oils were orally administered daily for 8 weeks. Plasma Hcy, phospholipids fatty acids, and mRNA expression were determined. Compared with the control group, plasma Hcy was significantly decreased in the 22:6n-3 and conjugated linoleic acid (CLA) groups; mRNA expression of Mthfr was significantly upregulated in the 22:6n-3, 20:5n-3, and 18:3n-3 groups and downregulated in the 18:2n-6 and stearolic acid (SO) groups. Mat1a was upregulated in the 22:6n-3, 20:5n-3, 18:3n-3, and CLA groups. In addition, Cbs was upregulated in the 22:6n-3, 20:5n-3, 18:3n-3 and CLA groups while downregulated in 18:2n-6 and SO groups. Dietary 22:6n-3 and CLA decrease the plasma concentration of Hcy. mRNA expression of Mthfr, Mat1a, Cbs and Pemt, Gnmt, Mtrr, and Bad is upregulated by n-3 PUFA and downregulated by n-6 PUFA. CLA upregulates mRNA expression of Mat1a and Cbs.

摘要

目的是研究多不饱和脂肪酸（PUFAs）对同型半胱氨酸（Hcy）代谢相关关键基因mRNA表达的调节作用。80只雄性Sprague Dawley大鼠被随机分为8组。每天经口给予油脂，持续8周。测定血浆Hcy、磷脂脂肪酸和mRNA表达。与对照组相比，22:6n-3和共轭亚油酸（CLA）组的血浆Hcy显著降低；22:6n-3、20:5n-3和18:3n-3组的Mthfr mRNA表达显著上调，而18:2n-6和硬脂酸（SO）组则下调。Mat1a在22:6n-3、20:5n-3、18:3n-3和CLA组中上调。此外，Cbs在22:6n-3、20:5n-3、18:3n-3和CLA组中上调，而在18:2n-6和SO组中下调。膳食中的22:6n-3和CLA可降低血浆Hcy浓度。n-3多不饱和脂肪酸上调Mthfr、Mat1a、Cbs和Pemt、Gnmt、Mtrr以及Bad的mRNA表达，n-6多不饱和脂肪酸则下调其表达。CLA上调Mat1a和Cbs的mRNA表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e19/3676954/b893099941dd/TSWJ2013-931626.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e19/3676954/cdfdaf59932c/TSWJ2013-931626.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e19/3676954/b893099941dd/TSWJ2013-931626.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e19/3676954/cdfdaf59932c/TSWJ2013-931626.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e19/3676954/b893099941dd/TSWJ2013-931626.002.jpg

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