Tachibana Tetsuya, Oikawa Daichi, Adachi Nami, Boswell Tim, Furuse Mitsuhiro
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug;147(4):1104-8. doi: 10.1016/j.cbpa.2007.03.023. Epub 2007 Mar 30.
Glucagon-like peptide-1 (GLP-1), derived from proglucagon, is thought to act as a negative regulator of energy homeostasis in mammals, since intracerebroventricular (ICV) injection of GLP-1 inhibits feeding behavior and enhances energy expenditure. The anorexigenic effect of GLP-1 is also observed in chicks, but whether brain GLP-1 enhances energy expenditure has not been investigated. The aim of the present study was to clarify the effect of ICV injection of GLP-1 on energy expenditure as well as metabolic changes in chicks. The injection of GLP-1 did not affect energy expenditure calculated from oxygen consumption and carbon dioxide production. On the other hand, the injection of GLP-1 significantly decreased respiratory quotient, suggesting that brain GLP-1 shifted the use of energy sources from carbohydrates to lipids. In support of this, ICV injection of GLP-1 increased plasma non-esterified fatty acid concentration while plasma glucose concentration was decreased. In conclusion, GLP-1 appears to act in the brain as a metabolic modulator rather than as a regulator of total energy expenditure in chicks.
胰高血糖素样肽-1（GLP-1）由胰高血糖素原衍生而来，被认为是哺乳动物能量稳态的负调节因子，因为脑室内（ICV）注射GLP-1会抑制摄食行为并增加能量消耗。在雏鸡中也观察到了GLP-1的厌食作用，但脑GLP-1是否会增加能量消耗尚未得到研究。本研究的目的是阐明ICV注射GLP-1对雏鸡能量消耗以及代谢变化的影响。GLP-1注射并未影响根据氧气消耗和二氧化碳产生计算出的能量消耗。另一方面，GLP-1注射显著降低了呼吸商，这表明脑GLP-1将能量来源的使用从碳水化合物转向了脂质。支持这一点的是，ICV注射GLP-1会增加血浆非酯化脂肪酸浓度，同时降低血浆葡萄糖浓度。总之，在雏鸡中，GLP-1似乎在大脑中作为一种代谢调节因子起作用，而不是作为总能量消耗的调节因子。
