Tachibana Tetsuya, Sato Momoka, Oikawa Daichi, Takahashi Hirokazu, Boswell Tim, Furuse Mitsuhiro
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Regul Pept. 2006 Sep 11;136(1-3):1-8. doi: 10.1016/j.regpep.2006.04.005. Epub 2006 May 19.
The purpose of the present study was to investigate whether intracerebroventricular (ICV) injection of neuropeptide Y (NPY) affects heat production (HP), body temperature, and plasma concentrations of metabolic fuels in chicks. ICV injection of NPY (0, 188 or 375 pmol) did not affect HP, but significantly lowered respiratory quotient as well as the rectal temperature. These data suggest that the energy sources for HP were modified by NPY in the body. This idea was confirmed by subsequent experiments in which ICV injection of NPY significantly reduced plasma glucose and triacylglycerol concentrations but increased non-esterified fatty acid concentrations. The effect of NPY on the utilization of metabolic fuels was not associated changes in plasma catecholamine and corticosterone concentrations. In summary, the present study demonstrated that central NPY modifies peripheral carbohydrate and lipid metabolism in chicks.
本研究的目的是探究脑室内（ICV）注射神经肽Y（NPY）是否会影响雏鸡的产热（HP）、体温以及代谢燃料的血浆浓度。脑室内注射NPY（0、188或375皮摩尔）对产热没有影响，但显著降低了呼吸商以及直肠温度。这些数据表明，NPY改变了体内产热的能量来源。随后的实验证实了这一观点，其中脑室内注射NPY显著降低了血浆葡萄糖和三酰甘油浓度，但增加了非酯化脂肪酸浓度。NPY对代谢燃料利用的影响与血浆儿茶酚胺和皮质酮浓度的变化无关。总之，本研究表明，中枢NPY改变了雏鸡外周碳水化合物和脂质的代谢。
